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Gut Microbiota and COVID-19: Potential Implications for Disease Severity.
Rocchi, Giulia; Giovanetti, Marta; Benedetti, Francesca; Borsetti, Alessandra; Ceccarelli, Giancarlo; Zella, Davide; Altomare, Annamaria; Ciccozzi, Massimo; Guarino, Michele Pier Luca.
  • Rocchi G; Department of Science and Engineering for Human and the Environment, University of Campus Bio-Medico, 00128 Rome, Italy.
  • Giovanetti M; Laboratorio de Flavivirus, lnstituto Oswaldo Cruz/Fundação Oswaldo Cruz, Rio de Janeiro 21040-360, Brazil.
  • Benedetti F; Department of Science and Technology for Humans and the Environment, University of Campus Bio-Medico, 00128 Rome, Italy.
  • Borsetti A; Institute of Human Virology and Global Virus Network Center, Department of Biochemistry and Molecular Biology, University of Maryland School of Medicine, Baltimore, MD 21201, USA.
  • Ceccarelli G; National HIV/AIDS Research Center, Istituto Superiore di Sanità, Viale Regina Elena, 299, 00161 Rome, Italy.
  • Zella D; Department of Public Health and Infectious Diseases, Sapienza University of Rome, 00161 Rome, Italy.
  • Altomare A; Institute of Human Virology and Global Virus Network Center, Department of Biochemistry and Molecular Biology, University of Maryland School of Medicine, Baltimore, MD 21201, USA.
  • Ciccozzi M; Department of Science and Technology for Humans and the Environment, University of Campus Bio-Medico, 00128 Rome, Italy.
  • Guarino MPL; Unit of Digestive Disease, Campus Bio-Medico University, 00128 Rome, Italy.
Pathogens ; 11(9)2022 Sep 15.
Article in English | MEDLINE | ID: covidwho-2043889
ABSTRACT
The SARS-CoV-2 pandemic resulted in an unprecedented global crisis. SARS-CoV-2 primarily causes lung infection trough the binding of the virus with the ACE-2 cell receptor located on the surface of the alveolar epithelial cells. Notably, ACE-2 cell receptors are also expressed in the epithelial cells of the intestinal tract (GI). Recent data showed that the microbial communities of the GI might act as local and systematic inflammatory modulators. Gastrointestinal symptoms, including diarrhea, are frequently observed in infected individuals, and recent released data indicate that SARS-CoV-2 may also spread by fecal-oral transmission. Moreover, the gut microbiota's ecosystem can regulate and be regulated by invading pathogens, including viruses, facilitating an effective immune response, which in turn results in less severe diseases. In this regard, increased SARS-CoV-2 mortality and morbidities appear to be frequently observed in elderly immunocompromised patients and in people with essential health problems, such as diabetes, who, indeed, tend to have a less diverse gut microbiota (dysbiosis). Therefore, it is important to understand how the interaction between the gut microbiota and SARS-CoV-2 might shape the intensity of the infection and different clinical outcomes. Here, we provide insights into the current knowledge of dysbiosis during SARS-CoV-2 infection and methods that may be used to re-establish a more correct microbiota composition.
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Full text: Available Collection: International databases Database: MEDLINE Type of study: Prognostic study / Systematic review/Meta Analysis Language: English Year: 2022 Document Type: Article Affiliation country: Pathogens11091050

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Full text: Available Collection: International databases Database: MEDLINE Type of study: Prognostic study / Systematic review/Meta Analysis Language: English Year: 2022 Document Type: Article Affiliation country: Pathogens11091050