Harnessing Human Papillomavirus' Natural Tropism to Target Tumors.
Viruses
; 14(8)2022 07 28.
Article
in English
| MEDLINE | ID: covidwho-2043971
ABSTRACT
Human papillomaviruses (HPV) are small non-enveloped DNA tumor viruses established as the primary etiological agent for the development of cervical cancer. Decades of research have elucidated HPV's primary attachment factor to be heparan sulfate proteoglycans (HSPG). Importantly, wounding and exposure of the epithelial basement membrane was found to be pivotal for efficient attachment and infection of HPV in vivo. Sulfation patterns on HSPG's become modified at the site of wounds as they serve an important role promoting tissue healing, cell proliferation and neovascularization and it is these modifications recognized by HPV. Analogous HSPG modification patterns can be found on tumor cells as they too require the aforementioned processes to grow and metastasize. Although targeting tumor associated HSPG is not a novel concept, the use of HPV to target and treat tumors has only been realized in recent years. The work herein describes how decades of basic HPV research has culminated in the rational design of an HPV-based virus-like infrared light activated dye conjugate for the treatment of choroidal melanoma.
Keywords
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Main subject:
Uveal Neoplasms
/
Papillomavirus Infections
/
Alphapapillomavirus
Type of study:
Etiology study
Limits:
Humans
Language:
English
Year:
2022
Document Type:
Article
Affiliation country:
V14081656
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