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Dynamics of B-Cell Responses after SARS-CoV-2 Vaccination in Spain.
José-Cascón, Miriam San; de la Varga-Martínez, Raquel; Campos-Caro, Antonio; Rodríguez, Carmen.
  • José-Cascón MS; Immunology Department, Hospital Universitario Puerta del Mar, 11009 Cádiz, Spain.
  • de la Varga-Martínez R; Immunology Department, Hospital Universitario Puerta del Mar, 11009 Cádiz, Spain.
  • Campos-Caro A; Biomedical Research and Innovation Institute of Cádiz (INiBICA), 11009 Cádiz, Spain.
  • Rodríguez C; Biomedical Research and Innovation Institute of Cádiz (INiBICA), 11009 Cádiz, Spain.
Vaccines (Basel) ; 10(10)2022 Sep 26.
Article in English | MEDLINE | ID: covidwho-2044053
ABSTRACT
The high mortality rate due to COVID-19 has necessitated the mass vaccination against SARS-CoV-2 to induce protective humoral and cellular immunity. (1)

Objective:

To study the dynamics of SARS-CoV-2-specific B cells after two doses of the Pfizer-BioNTech SARS-CoV-2 vaccine. (2)

Methods:

Immunophenotyping and cellular cultures were used to determine the kinetics of B-cell subpopulations and vaccine responses in volunteers before and seven days, three months and seven months after the second dose in Spain (n = 19). (3)

Results:

Seven days after immunisation, memory B cells and plasmablasts expressing receptors for factors implicated in the maturation of plasma cells were augmented in blood. Three months after vaccination, SARS-CoV-2 spike-specific plasmablasts disappeared from circulation while spike-specific memory-B cells circulated, with heterogeneous dynamics among individuals. (4)

Conclusion:

After vaccination, specific plasmablasts equipped with receptors for maturation factors were quickly generated and disappeared rapidly from the blood, while specific memory B cells circulated for at least seven months.
Keywords

Full text: Available Collection: International databases Database: MEDLINE Topics: Vaccines Language: English Year: 2022 Document Type: Article Affiliation country: Vaccines10101615

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Full text: Available Collection: International databases Database: MEDLINE Topics: Vaccines Language: English Year: 2022 Document Type: Article Affiliation country: Vaccines10101615