Improving the treatment of the novel coronavirus infection (COVID-19) in children at risk for the development of severe disease with the use of virus-neutralizing monoclonal antibodies
Rossiyskiy Vestnik Perinatologii i Pediatrii
; 67(3):23-33, 2022.
Article
in Russian
| EMBASE | ID: covidwho-2044315
ABSTRACT
This study presents the results of treatment of 98 patients with risk of development of severe coronavirus disease (hereinafter COVID-19) with the first positive result of polymerase chain reaction test for SARS-CoV-2 in a day clinic of the multidisciplinary Z.A. Bashlyaeva Children’s Municipal Clinical Hospital. To prevent the clinical manifestation of COVID-19 and the progression of the main disease all these children were treated with virus-neutralizing monoclonal antibodies (sotrovimab 500 mg dissolved in 92 mL of 0.9% sodium chloride solution intravenously for 30 minutes, once, for children over 12 years old and with body weight over 12 kg;balanivimab 700 mg + etesivimab 1400 mg pre-dissolved in 250 mL of 0.9% sodium chloride solution intravenously for 30 minutes, once). Patients underwent a comprehensive clinical, laboratory and instrumental examination both initially and in dynamics for 3–7–11 days after therapy according to the developed clinical algorithm. The effectiveness of biological therapy in children with a risk of severe COVID-19 was noted in 100% of cases. None of the observed patients had either a clinical manifestation of COVID-19 or a relapse of the main chronic disease.
algorithm; article; body weight; child; chronic disease; clinical laboratory; controlled study; coronavirus disease 2019; COVID-19 testing; drug therapy; female; gene amplification; human; intravenous drug administration; major clinical study; male; nonhuman; outpatient department; polymerase chain reaction; prevention; Severe acute respiratory syndrome coronavirus 2; neutralizing antibody; sodium chloride; sotrovimab
Full text:
Available
Collection:
Databases of international organizations
Database:
EMBASE
Type of study:
Prognostic study
Language:
Russian
Journal:
Rossiyskiy Vestnik Perinatologii i Pediatrii
Year:
2022
Document Type:
Article
Similar
MEDLINE
...
LILACS
LIS