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The Impact of SARS-CoV-2 on Mental Health. Focus on depression, Antidepressants Consumption and ADRs Signal Detection: An International Journal of Medical Toxicology and Drug Experience
Drug Safety ; 45(10):1176-1177, 2022.
Article in English | ProQuest Central | ID: covidwho-2047123
ABSTRACT

Introduction:

The SARS-CoV-2 public health emergency is leading to challenges for healthcare professionals, students, patients with COVID-19 and vulnerable persons, blocking the economic development and mental wellbeing. The pandemic containment measures and the fear of infection have caused psychological distress and inflamed underlying diseases

Objective:

To analyse the impact of the SARS-CoV-2 on the Mental Health in Friuli-Venezia Giulia Region, Italy, focusing on depression disorder and Antidepressants consumption. Furthermore, to assess the state of adverse event reports, from spontaneous signalling method, in patients taking Antidepressants

Methods:

For consumption data extraction I utilized the Regional Social and Health Information System. About reports of ADRs based on the National Pharmacovigilance Network I used the VigiSegn app. I accessed on INTERCheck System to balancing the risks and benefits of therapies. I compared two periods from 11.03.2019 to 10.03.2020 and from 11.03.2020 to 11.03.2021 separated by 11 March 2020, when the Director General of the WHO described the situation as a pandemic [1]. Antidepressants were classified using the ATC code system. Anonymous drug utilization was expressed in DDDs

Results:

Since 11 March 2020 I observed a marginal increase in consumption of sertraline, trazodone and vortioxetine. Regarding pharmaceutical spending there has been an increase of sertraline, trazodone, vortioxetine, bupropion, mirtazapine and venlafaxine. In the feminine gender, I observed an increase in AD consumption in the age ranges < 15 yrs, 16-19, 30-34, 55-59, 60-64, 70-74, 80-84, over 85;in the male gender in the ranges < 15 yrs, 20-24, 30-34, 55-59, 70-74, 80-84, over 85 (Picture 1). Concerning ADRs I analysed one tab about AD out of a total of 2146 medicines and vaccines reports in which the "hyponatremia" is reported on the warning label and caused by significant drug interactions

Conclusion:

Although the SARS-CoV-2 public health emergency is a rapidly evolving situation, the knowledge about the impact on the Mental Health is still limited. It is likely that the psychosocial demand will increase in the coming months. In the regional context, the thesis has highlighted a very slight rise in AD consumptions and a cant decrease spontaneous signalling method compared to the previous year. These scenarios also depend on the new balance of health services and the lack of access to care (10% of citizens has given up on care) [13, 14]. The healthcare systems will have to face important challenges and the success of the creation of high-quality healthcare reality will depend on the alliance between healthcare specialists
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Collection: Databases of international organizations Database: ProQuest Central Type of study: Experimental Studies / Prognostic study / Reviews Topics: Vaccines Language: English Journal: Drug Safety Year: 2022 Document Type: Article

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Collection: Databases of international organizations Database: ProQuest Central Type of study: Experimental Studies / Prognostic study / Reviews Topics: Vaccines Language: English Journal: Drug Safety Year: 2022 Document Type: Article