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Excess risk for acute myocardial infarction mortality during the COVID-19 pandemic.
Yeo, Yee Hui; Wang, Maggie; He, Xinyuan; Lv, Fan; Zhang, Yue; Zu, Jian; Li, Mei; Jiao, Yang; Ebinger, Joseph E; Patel, Jignesh K; Cheng, Susan; Ji, Fanpu.
  • Yeo YH; Division of General Internal Medicine, Cedars-Sinai Medical Center, Los Angeles, California, USA.
  • Wang M; Division of General Internal Medicine, Cedars-Sinai Medical Center, Los Angeles, California, USA.
  • He X; Department of Infectious Disease, The Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi, China.
  • Lv F; Department of Applied Mathematics, School of Mathematics and Statistics, Xi'an Jiaotong University, Xi'an, Shaanxi, China.
  • Zhang Y; Department of Infectious Disease, The Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi, China.
  • Zu J; Fourth Department of Liver Diseases, The Eighth Hospital of Xi'an City, Xi'an Jiaotong University, Xi'an, Shaanxi, China.
  • Li M; Department of Applied Mathematics, School of Mathematics and Statistics, Xi'an Jiaotong University, Xi'an, Shaanxi, China.
  • Jiao Y; Department of Infectious Disease, The Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi, China.
  • Ebinger JE; Department of Endocrinology, The Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi, China.
  • Patel JK; Department of Cardiology, Smidt Heart Institute, Cedars-Sinai Medical Center, Los Angeles, California, USA.
  • Cheng S; Department of Cardiology, Smidt Heart Institute, Cedars-Sinai Medical Center, Los Angeles, California, USA.
  • Ji F; Department of Cardiology, Smidt Heart Institute, Cedars-Sinai Medical Center, Los Angeles, California, USA.
J Med Virol ; 2022 Sep 29.
Article in English | MEDLINE | ID: covidwho-2237294
ABSTRACT
The COVID-19 pandemic has had a detrimental impact on the healthcare system. Our study armed to assess the extent and the disparity in excess acute myocardial infarction (AMI)-associated mortality during the pandemic, through the recent Omicron outbreak. Using data from the CDC's National Vital Statistics System, we identified 1 522 669 AMI-associated deaths occurring between 4/1/2012 and 3/31/2022. Accounting for seasonality, we compared age-standardized mortality rate (ASMR) for AMI-associated deaths between prepandemic and pandemic periods, including observed versus predicted ASMR, and examined temporal trends by demographic groups and region. Before the pandemic, AMI-associated mortality rates decreased across all subgroups. These trends reversed during the pandemic, with significant rises seen for the youngest-aged females and males even through the most recent period of the Omicron surge (10/2021-3/2022). The SAPC in the youngest and middle-age group in AMI-associated mortality increased by 5.3% (95% confidence interval [CI] 1.6%-9.1%) and 3.4% (95% CI 0.1%-6.8%), respectively. The excess death, defined as the difference between the observed and the predicted mortality rates, was most pronounced for the youngest (25-44 years) aged decedents, ranging from 23% to 34% for the youngest compared to 13%-18% for the oldest age groups. The trend of mortality suggests that age and sex disparities have persisted even through the recent Omicron surge, with excess AMI-associated mortality being most pronounced in younger-aged adults.
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Full text: Available Collection: International databases Database: MEDLINE Type of study: Experimental Studies / Prognostic study / Randomized controlled trials Topics: Variants Language: English Year: 2022 Document Type: Article Affiliation country: Jmv.28187

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Full text: Available Collection: International databases Database: MEDLINE Type of study: Experimental Studies / Prognostic study / Randomized controlled trials Topics: Variants Language: English Year: 2022 Document Type: Article Affiliation country: Jmv.28187