Impact of COVID-19 versus chronic rhinosinusitis/rhinitis associated olfactory dysfunction on health utility and quality of life.
Laryngoscope Investig Otolaryngol
; 2022 Sep 24.
Article
in English
| MEDLINE | ID: covidwho-2047824
ABSTRACT
Background:
Olfactory dysfunction (OD) is associated with both post-viral and inflammatory etiologies such as COVID-19 and chronic rhinosinusitis/rhinitis (CRS/R) respectively, to result in reduced quality of life (QoL). However, the former typically induces a sudden-onset OD while the latter has a gradual presentation. This study aims to establish and compare health utility values (HUVs) and olfactory-specific QoL measurements between patients with COVID-19 and CRS/R related OD.Methods:
This prospective study surveyed COVID-19 and CRS/R patients with self-reported OD using HUV assessments (EuroQol-visual analog scale [EQ-VAS], EuroQol-5 dimension [EQ-5D], time trade-off [TTO]) and olfactory and sinonasal QoL measures (questionnaire of olfactory disorders -negative and positive statements [QOD-NS + PS] and sino-nasal outcome test [SNOT-22]). A subgroup of subjects completed objective olfactory testing. Intergroup mean scores were compared using Mann-Whitney U tests.Results:
One hundred eleven subjects were enrolled mean age ± SD (43.0 ± 15.4 years), 55.9% female. CRS/R was associated with lower HUVs as measured by EQ-VAS (CRS/R 0.67 ± 0.18 vs. COVID-19 0.74 ± 0.19, p = .03) and worse SNOT-22 scores in both overall (CRS/R 49.03 ± 21.04 vs. COVID-19 27.58 ± 18.45, p < .001) and subgroup analysis of objectively confirmed OD subjects (CRS/R 52.40 ± 22.78 vs. COVID-19 29.84 ± 21.10, p = .01). On the other hand, COVID-19 has greater burden on olfactory-specific QoL (QOD-NS + PS, COVID-19 23.19 ± 13.73 vs. CRS/R 17.25 ± 11.38, p = .04). Both groups demonstrated a similar decrease in health using the EQ-5D assessment.Conclusion:
CRS/R associated OD has a more severe impact on general health and sinonasal specific QoL outcomes, while COVID-19 associated OD has a greater burden on olfactory-specific QoL. Level of evidence Level 2c.
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Type of study:
Cohort study
/
Etiology study
/
Experimental Studies
/
Observational study
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Prognostic study
/
Randomized controlled trials
Language:
English
Year:
2022
Document Type:
Article
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