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Comparative analysis of single cell lung atlas of bat, cat, tiger, and pangolin.
Wang, Xiran; Ding, Peiwen; Sun, Chengcheng; Wang, Daxi; Zhu, Jiacheng; Wu, Wendi; Wei, Yanan; Xiang, Rong; Ding, Xiangning; Luo, Lihua; Li, Meiling; Zhang, Wensheng; Jin, Xin; Sun, Jian; Liu, Huan; Chen, Dongsheng.
  • Wang X; National Risk Assessment Laboratory for Antimicrobial Resistance of Animal Original Bacteria, South China Agricultural University, Guangzhou, China.
  • Ding P; Guangdong Laboratory for Lingnan Modern Agriculture, Guangzhou, China.
  • Sun C; BGI-Shenzhen, Shenzhen, 518083, China.
  • Wang D; College of Life Sciences, University of Chinese Academy of Sciences, Beijing, 100049, China.
  • Zhu J; BGI-Shenzhen, Shenzhen, 518083, China.
  • Wu W; College of Life Sciences, University of Chinese Academy of Sciences, Beijing, 100049, China.
  • Wei Y; School of Basic Medicine, Qingdao University, Qingdao, 266071, China.
  • Xiang R; BGI-Shenzhen, Shenzhen, 518083, China.
  • Ding X; Shenzhen Key Laboratory of Unknown Pathogen Identification, BGI-Shenzhen, Shenzhen, 518083, China.
  • Luo L; BGI-Shenzhen, Shenzhen, 518083, China.
  • Li M; College of Life Sciences, University of Chinese Academy of Sciences, Beijing, 100049, China.
  • Zhang W; BGI-Shenzhen, Shenzhen, 518083, China.
  • Jin X; College of Life Sciences, University of Chinese Academy of Sciences, Beijing, 100049, China.
  • Sun J; School of Basic Medicine, Qingdao University, Qingdao, 266071, China.
  • Liu H; BGI-Shenzhen, Shenzhen, 518083, China.
  • Chen D; College of Life Sciences, University of Chinese Academy of Sciences, Beijing, 100049, China.
Cell Biol Toxicol ; 2022 Sep 28.
Article in English | MEDLINE | ID: covidwho-2048355
ABSTRACT
Horseshoe bats (Rhinolophus sinicus) might help maintain coronaviruses severely affecting human health, such as severe acute respiratory syndrome coronavirus (SARS-CoV). Bats may be more tolerant of viral infection than other mammals due to their unique immune system, but the exact mechanism remains to be fully explored. During the coronavirus disease 2019 (COVID-19) pandemic, multiple animal species were diseased by coronavirus infection, especially in the respiratory system. Herein, a comparative analysis with single nucleus transcriptomic data of the lungs across four species, including horseshoe bat, cat, tiger, and pangolin, were conducted. The distribution of entry factors for twenty-eight respiratory viruses was characterized for the four species. Our findings might increase our understanding of the immune background of horseshoe bats.
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Full text: Available Collection: International databases Database: MEDLINE Language: English Journal subject: Toxicology Year: 2022 Document Type: Article Affiliation country: S10565-022-09771-9

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Full text: Available Collection: International databases Database: MEDLINE Language: English Journal subject: Toxicology Year: 2022 Document Type: Article Affiliation country: S10565-022-09771-9