Discovery of a tRNA-like base sequence in the coronavirus genome and possible mechanism of action.
Genes Genomics
; 44(11): 1399-1404, 2022 11.
Article
in English
| MEDLINE | ID: covidwho-2048615
ABSTRACT
BACKGROUND:
The question of whether the coronavirus genome contain as-yetununderstood genetic component. PURPOSE (OBJECTIVE) Elucidate the novel functions of the discovered tRNA-like base sequence and lead to the development of novel therapeutic agents.METHODS:
A novel tRNA-like base sequence was found in the sequences complementary to the genomes of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and SARS-CoV. By comparing mutations in the tRNA-like base sequences of these two viruses, it was found that base pairing in the cloverleaf model of SARS-CoV-2 was more robust than that of SARS-CoV.RESULTS:
The results of homology search between a short sequence of the coronavirus tRNA-like base sequence and human genes suggest that the molecule produced by this novel tRNA-like sequence may be involved in the splicing of human messenger RNA.CONCLUSIONS:
Experimental molecular evidence of the tRNA-like base sequence discovered in this study is urgently needed.Keywords
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Main subject:
SARS-CoV-2
/
COVID-19
Limits:
Humans
Language:
English
Journal:
Genes Genomics
Year:
2022
Document Type:
Article
Affiliation country:
S13258-022-01299-w
Similar
MEDLINE
...
LILACS
LIS