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Determination of soluble angiotensin-converting enzyme 2 in saliva samples and its association with nicotine.
Bru, Samuel; González-Marrón, Adrián; Lidón-Moyano, Cristina; Carballar, Reyes; Martínez-Láinez, Joan Marc; Pérez-Martín, Hipólito; Fu, Marcela; Pérez-Ortuño, Raúl; Ballbè, Montse; Pascual, Jose A; Fernández, Esteve; Clotet, Josep; Martínez-Sánchez, Jose M.
  • Bru S; Department of Basic Sciences, Universitat Internacional de Catalunya, Sant Cugat Del Vallès, Barcelona, Spain.
  • González-Marrón A; Group of Evaluation of Health Determinants and Health Policies, Department of Basic Sciences, Universitat Internacional de Catalunya, Sant Cugat Del Vallès, Barcelona, Spain.
  • Lidón-Moyano C; Group of Evaluation of Health Determinants and Health Policies, Department of Basic Sciences, Universitat Internacional de Catalunya, Sant Cugat Del Vallès, Barcelona, Spain.
  • Carballar R; Department of Basic Sciences, Universitat Internacional de Catalunya, Sant Cugat Del Vallès, Barcelona, Spain.
  • Martínez-Láinez JM; Department of Basic Sciences, Universitat Internacional de Catalunya, Sant Cugat Del Vallès, Barcelona, Spain.
  • Pérez-Martín H; Group of Evaluation of Health Determinants and Health Policies, Department of Basic Sciences, Universitat Internacional de Catalunya, Sant Cugat Del Vallès, Barcelona, Spain.
  • Fu M; Tobacco Control Unit, Catalan Institute of Oncology - ICO, WHO Collaborating Centre for Tobacco Control, L'Hospitalet de Llobregat, Barcelona, Spain; Tobacco Control Research Group, Bellvitge Biomedical Research Institute - IDIBELL, L'Hospitalet de Llobregat, Barcelona, Spain; School of Medicine and
  • Pérez-Ortuño R; Group of Integrative Pharmacology and Systems Neuroscience, Neurosciences Programme, IMIM (Hospital Del Mar Medical Research Institute), Parc de Recerca Biomèdica de Barcelona, Barcelona, Spain.
  • Ballbè M; Tobacco Control Unit, Catalan Institute of Oncology - ICO, WHO Collaborating Centre for Tobacco Control, L'Hospitalet de Llobregat, Barcelona, Spain; Tobacco Control Research Group, Bellvitge Biomedical Research Institute - IDIBELL, L'Hospitalet de Llobregat, Barcelona, Spain; Centro de Investigació
  • Pascual JA; Department of Medicine and Life Sciences, Universitat Pompeu Fabra, Barcelona Biomedical Research Park, Barcelona, Spain.
  • Fernández E; Tobacco Control Unit, Catalan Institute of Oncology - ICO, WHO Collaborating Centre for Tobacco Control, L'Hospitalet de Llobregat, Barcelona, Spain; Tobacco Control Research Group, Bellvitge Biomedical Research Institute - IDIBELL, L'Hospitalet de Llobregat, Barcelona, Spain; School of Medicine and
  • Clotet J; Department of Basic Sciences, Universitat Internacional de Catalunya, Sant Cugat Del Vallès, Barcelona, Spain. Electronic address: jclotet@uic.es.
  • Martínez-Sánchez JM; Group of Evaluation of Health Determinants and Health Policies, Department of Basic Sciences, Universitat Internacional de Catalunya, Sant Cugat Del Vallès, Barcelona, Spain. Electronic address: jmmartinez@uic.es.
Environ Res ; 216(Pt 1): 114443, 2023 01 01.
Article in English | MEDLINE | ID: covidwho-2049189
ABSTRACT

INTRODUCTION:

The Angiotensin-Converting Enzyme 2 (ACE2) is the main receptor of the SARS-CoV-2. There is contradictory evidence on how the exposure to nicotine may module the concentration of soluble ACE2 (sACE2). The aim of this study was to assess the association between nicotine and sACE2 concentrations in saliva samples.

METHODS:

Pooled analysis performed with data retrieved from two studies (n = 634 and n = 302). Geometric mean (GM) concentrations of sACE2, both total and relative to the total amount of protein in the sample, were compared according to sociodemographic variables and variables associated to nicotine. Multivariable linear regression models were fitted to explore the associations of sACE2 with nicotine adjusting for sex, age and body mass index. Spearman's rank-correlation coefficients were estimated between the concentrations of nicotine and cotinine, and pack-years, the concentration of relative sACE2 and the isoforms of sACE2.

RESULTS:

We observed a significant increase of 0.108‰ and 0.087 ng/µl in the relative and absolute salivary sACE2 GM concentrations, respectively, between the lowest and highest nicotine levels. Similar results were observed for cotinine. These associations did not change in the multivariable linear models. There was a low correlation of nicotine and cotinine concentration with the concentration of relative salivary sACE2 (rs = 0.153 and rs = 0.132, respectively), pack-years (rs = 0.222 and rs = 0.235, respectively) and with the concentration of isoform 40 KDa (rs = 0.193 and rs = 0.140, respectively).

CONCLUSION:

Salivary nicotine concentration seems to be limitedly associated with the concentration of sACE2.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Saliva / Angiotensin-Converting Enzyme 2 / Nicotine Type of study: Reviews Limits: Humans Language: English Journal: Environ Res Year: 2023 Document Type: Article Affiliation country: J.envres.2022.114443

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Saliva / Angiotensin-Converting Enzyme 2 / Nicotine Type of study: Reviews Limits: Humans Language: English Journal: Environ Res Year: 2023 Document Type: Article Affiliation country: J.envres.2022.114443