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Comparative efficacy evaluation of disinfectants against severe acute respiratory syndrome coronavirus-2.
Lee, G-H; Park, S-H; Song, B-M; Kim, D-M; Han, H-J; Park, J-Y; Jo, Y-W; Hwang, M-Y; Sim, K-T; Kang, S-M; Tark, D.
  • Lee GH; Laboratory for Infectious Disease Prevention, Korea Zoonosis Research Institute, Jeonbuk National University, Iksan, Republic of Korea.
  • Park SH; Laboratory for Infectious Disease Prevention, Korea Zoonosis Research Institute, Jeonbuk National University, Iksan, Republic of Korea.
  • Song BM; Laboratory for Infectious Disease Prevention, Korea Zoonosis Research Institute, Jeonbuk National University, Iksan, Republic of Korea.
  • Kim DM; Laboratory for Infectious Disease Prevention, Korea Zoonosis Research Institute, Jeonbuk National University, Iksan, Republic of Korea.
  • Han HJ; Laboratory for Infectious Disease Prevention, Korea Zoonosis Research Institute, Jeonbuk National University, Iksan, Republic of Korea.
  • Park JY; Laboratory for Infectious Disease Prevention, Korea Zoonosis Research Institute, Jeonbuk National University, Iksan, Republic of Korea.
  • Jo YW; Division of Chemical Research, National Institute of Environmental Research, Incheon, Republic of Korea.
  • Hwang MY; Division of Chemical Research, National Institute of Environmental Research, Incheon, Republic of Korea.
  • Sim KT; Division of Chemical Research, National Institute of Environmental Research, Incheon, Republic of Korea.
  • Kang SM; Laboratory for Infectious Disease Prevention, Korea Zoonosis Research Institute, Jeonbuk National University, Iksan, Republic of Korea. Electronic address: sangminkang@jbnu.ac.kr.
  • Tark D; Laboratory for Infectious Disease Prevention, Korea Zoonosis Research Institute, Jeonbuk National University, Iksan, Republic of Korea. Electronic address: tarkds@jbnu.ac.kr.
J Hosp Infect ; 131: 12-22, 2022 Sep 30.
Article in English | MEDLINE | ID: covidwho-2242551
ABSTRACT

BACKGROUND:

Disinfection is one of the most effective ways to block the rapid transmission of severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2). Due to the prolonged coronavirus disease 2019 (COVID-19) pandemic, disinfectants have become crucial to prevent person-to-person transmission and decontaminate hands, clothes, facilities and equipment. However, there is a lack of accurate information on the virucidal activity of commercial disinfectants.

AIM:

To evaluate the virucidal efficacy of 72 commercially available disinfectants constituting 16 types of ingredients against SARS-CoV-2.

METHODS:

SARS-CoV-2 was tested with various concentrations of disinfectants at indicated exposure time points as recommended by the manufacturers. The 50% tissue culture infectious dose assay was used to calculate virus titre, and trypan blue staining and CCK-8 were used to assess cell viability after 3-5 days of SARS-CoV-2 infection.

FINDINGS:

This study found that disinfectants based on 83% ethanol, 60% propanol/ethanol, 0.00108-0.0011% sodium dichloroisocyanurate and 0.497% potassium peroxymonosulfate inactivated SARS-CoV-2 effectively and safely. Although disinfectants based on 0.05-0.4% benzalkonium chloride (BAC), 0.02-0.07% quaternary ammonium compound (QAC; 11), 0.4% BAC/didecyldimethylammonium chloride (DDAC), 0.28% benzethonium chloride concentrate/2-propanol, 0.0205-0.14% DDAC/polyhexamethylene biguanide hydrochloride (PHMB) and 0.5% hydrogen peroxide inactivated SARS-CoV-2 effectively, they exhibited cytotoxicity. Conversely, disinfectants based on 0.04-4% QAC (23), 0.00625% BAC/DDAC/PHMB, and 0.0205-0.14% and 0.0173% peracetic acid showed approximately 50% virucidal efficacy with no cytotoxicity. Citric acid (0.4%) did not inactivate SARS-CoV-2.

CONCLUSION:

These results indicate that most commercially available disinfectants exert a disinfectant effect against SARS-CoV-2. However, re-evaluation of the effective concentration and exposure time of certain disinfectants is needed, especially citric acid and peracetic acid.
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Full text: Available Collection: International databases Database: MEDLINE Type of study: Experimental Studies Language: English Journal: J Hosp Infect Year: 2022 Document Type: Article

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Full text: Available Collection: International databases Database: MEDLINE Type of study: Experimental Studies Language: English Journal: J Hosp Infect Year: 2022 Document Type: Article