Water-soluble inclusion complexes for a novel anti-viral agent with low toxicity;Oseltamivir with the β-cyclodextrins
Journal of Molecular Liquids
; 366, 2022.
Article
in English
| Scopus | ID: covidwho-2049679
ABSTRACT
An innovative sonication method has been developed to produce inclusion complexes (ICs) of Oseltamivir (OTV) which is a potentially water-soluble anti-viral agent with lesser cytotoxicity. Proton signals and chemical shifts of OTV without any ambiguity confirm the formation of ICs with β-Cyclodextrin (B-CD) and Hydroxypropyl-β-cyclodextrin (H-CD). ICs are also supported by their atomic percentages as secondary evidence using XPS analysis. Analysis of drug release at three pH levels revealed the slow release of the OTV from ICs and also suitable for viral inactivation. A very less cytotoxic ability on cancer cell lines and enhanced the viral inactivation of OTV after being made into water-soluble ICs. © 2022 Elsevier B.V.
Corona virus inactivation; Cyclodextrins; Drug delivery; Inclusion materials; Oseltamivir; Toxicity; Cell culture; Controlled drug delivery; Integrated circuits; Targeted drug delivery; Viruses; Inclusion complex; Inclusion material; Low toxicity; Proton signals; Sonication method; Viral inactivation; Virus inactivation; Watersoluble
Full text:
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Collection:
Databases of international organizations
Database:
Scopus
Language:
English
Journal:
Journal of Molecular Liquids
Year:
2022
Document Type:
Article
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