Acute respiratory distress syndrome: causes, pathophysiology, and phenotypes.
Lancet
; 400(10358): 1145-1156, 2022 10 01.
Article
in English
| MEDLINE | ID: covidwho-2050101
ABSTRACT
Acute respiratory distress syndrome (ARDS) is a common clinical syndrome of acute respiratory failure as a result of diffuse lung inflammation and oedema. ARDS can be precipitated by a variety of causes. The pathophysiology of ARDS is complex and involves the activation and dysregulation of multiple overlapping and interacting pathways of injury, inflammation, and coagulation, both in the lung and systemically. Mechanical ventilation can contribute to a cycle of lung injury and inflammation. Resolution of inflammation is a coordinated process that requires downregulation of proinflammatory pathways and upregulation of anti-inflammatory pathways. The heterogeneity of the clinical syndrome, along with its biology, physiology, and radiology, has increasingly been recognised and incorporated into identification of phenotypes. A precision-medicine approach that improves the identification of more homogeneous ARDS phenotypes should lead to an improved understanding of its pathophysiological mechanisms and how they differ from patient to patient.
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Main subject:
Respiratory Distress Syndrome
Type of study:
Prognostic study
Limits:
Humans
Language:
English
Journal:
Lancet
Year:
2022
Document Type:
Article
Affiliation country:
S0140-6736(22)01485-4
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