Wychimicins, a new class of spirotetronate polyketides from Actinocrispum wychmicini MI503-A4.
J Antibiot (Tokyo)
; 75(10): 535-541, 2022 10.
Article
in English
| MEDLINE | ID: covidwho-2050352
ABSTRACT
In the course of our screening program for new anti-methicillin-resistant Staphylococcus aureus antibiotics, four novel antibiotics, termed wychimicins A-D, were isolated from the culture broth of the rare actinomycete Actinocrispum wychmicini strain MI503-AF4. Wychimicins are spirotetronates possessing a macrocyclic 13-membered ring containing trans-decalin and ß-D-xylo-hexopyranose moieties connected to C-17 by an O-glycosidic linkage according to MS, NMR and X-ray analyses. In X-ray crystal structure analysis, the Flack constant was 0.10 (11). The stereochemistry of the spirocarbon C-25 was R. Wychimicins had a minimum inhibitory concentration of 0.125-2 µg ml-1 against methicillin-resistant Staphylococcus aureus.
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Main subject:
Actinomycetales
/
Actinobacteria
/
Methicillin-Resistant Staphylococcus aureus
/
Polyketides
Type of study:
Prognostic study
Language:
English
Journal:
J Antibiot (Tokyo)
Year:
2022
Document Type:
Article
Affiliation country:
S41429-022-00560-4
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