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Iron status and the risk of sepsis and severe COVID-19: a two-sample Mendelian randomization study.
Mohus, Randi Marie; Flatby, Helene; Liyanarachi, Kristin V; DeWan, Andrew T; Solligård, Erik; Damås, Jan Kristian; Åsvold, Bjørn Olav; Gustad, Lise T; Rogne, Tormod.
  • Mohus RM; Gemini Center for Sepsis Research, Institute of Circulation and Medical Imaging, NTNU, Norwegian University of Science and Technology, Trondheim, Norway. randi.m.mohus@ntnu.no.
  • Flatby H; Clinic of Anesthesia and Intensive Care, St. Olavs Hospital, Trondheim University Hospital, Postboks 3250 Torgarden, 7006, Trondheim, Norway. randi.m.mohus@ntnu.no.
  • Liyanarachi KV; Gemini Center for Sepsis Research, Institute of Circulation and Medical Imaging, NTNU, Norwegian University of Science and Technology, Trondheim, Norway.
  • DeWan AT; Gemini Center for Sepsis Research, Institute of Circulation and Medical Imaging, NTNU, Norwegian University of Science and Technology, Trondheim, Norway.
  • Solligård E; Department of Infectious Diseases, St. Olavs Hospital, Trondheim University Hospital, Trondheim, Norway.
  • Damås JK; Gemini Center for Sepsis Research, Institute of Circulation and Medical Imaging, NTNU, Norwegian University of Science and Technology, Trondheim, Norway.
  • Åsvold BO; Department of Chronic Disease Epidemiology and Center for Perinatal, Pediatric and Environmental Epidemiology, Yale School of Public Health, New Haven, CT, USA.
  • Gustad LT; Gemini Center for Sepsis Research, Institute of Circulation and Medical Imaging, NTNU, Norwegian University of Science and Technology, Trondheim, Norway.
  • Rogne T; Gemini Center for Sepsis Research, Institute of Circulation and Medical Imaging, NTNU, Norwegian University of Science and Technology, Trondheim, Norway.
Sci Rep ; 12(1): 16157, 2022 09 28.
Article in English | MEDLINE | ID: covidwho-2050541
ABSTRACT
Observational studies have indicated an association between iron status and risk of sepsis and COVID-19. We estimated the effect of genetically-predicted iron biomarkers on risk of sepsis and risk of being hospitalized with COVID-19, performing a two-sample Mendelian randomization study. For risk of sepsis, one standard deviation increase in genetically-predicted serum iron was associated with odds ratio (OR) of 1.14 (95% confidence interval [CI] 1.01-1.29, P = 0.031). The findings were supported in the analyses for transferrin saturation and total iron binding capacity, while the estimate for ferritin was inconclusive. We found a tendency of higher risk of hospitalization with COVID-19 for serum iron; OR 1.29 (CI 0.97-1.72, P = 0.08), whereas sex-stratified analyses showed OR 1.63 (CI 0.94-2.86, P = 0.09) for women and OR 1.21 (CI 0.92-1.62, P = 0.17) for men. Sensitivity analyses supported the main findings and did not suggest bias due to pleiotropy. Our findings suggest a causal effect of genetically-predicted higher iron status and risk of hospitalization due to sepsis and indications of an increased risk of being hospitalized with COVID-19. These findings warrant further studies to assess iron status in relation to severe infections, including the potential of improved management.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Sepsis / COVID-19 Type of study: Experimental Studies / Observational study / Prognostic study Limits: Female / Humans / Male Language: English Journal: Sci Rep Year: 2022 Document Type: Article Affiliation country: S41598-022-20679-6

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Sepsis / COVID-19 Type of study: Experimental Studies / Observational study / Prognostic study Limits: Female / Humans / Male Language: English Journal: Sci Rep Year: 2022 Document Type: Article Affiliation country: S41598-022-20679-6