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Optimized parameters for effective SARS-CoV-2 inactivation using UVC-LED at 275 nm.
Lee, Cheulkyu; Park, Ki Hoon; Kim, Minjee; Kim, Young Bong.
  • Lee C; Transportation Environmental Research Team, Korea Railroad Research Institute, 176, Cheoldobangmulgwan-ro, Uiwang-si, Gyeonggi-do, Republic of Korea.
  • Park KH; Department of Biomedical Science and Engineering, KU Convergence Science and Technology Institute, Konkuk University, Seoul, 05029, Republic of Korea.
  • Kim M; Department of Biomedical Science and Engineering, KU Convergence Science and Technology Institute, Konkuk University, Seoul, 05029, Republic of Korea. kimera@konkuk.ac.kr.
  • Kim YB; Department of Biomedical Science and Engineering, KU Convergence Science and Technology Institute, Konkuk University, Seoul, 05029, Republic of Korea. mj0411@konkuk.ac.kr.
Sci Rep ; 12(1): 16664, 2022 10 05.
Article in English | MEDLINE | ID: covidwho-2050544
ABSTRACT
The spread of SARS-CoV-2 infections and the severity of the coronavirus disease of 2019 (COVID-19) pandemic have resulted in the rapid development of medications, vaccines, and countermeasures to reduce viral transmission. Although new treatment strategies for preventing SARS-CoV-2 infection are available, viral mutations remain a serious threat to the healthcare community. Hence, medical devices equipped with virus-eradication features are needed to prevent viral transmission. UV-LEDs are gaining popularity in the medical field, utilizing the most germicidal UVC spectrum, which acts through photoproduct formation. Herein, we developed a portable and rechargeable medical device that can disinfect SARS-CoV-2 in less than 10 s by 99.9%, lasting 6 h. Using this device, we investigated the antiviral effect of UVC-LED (275 nm) against SARS-CoV-2 as a function of irradiation distance and exposure time. Irradiation distance of 10-20 cm, < 10 s exposure time, and UV doses of > 10 mJ/cm2 were determined optimal for SARS-CoV-2 elimination (≥ 99.99% viral reduction). The UVC-LED systems have advantages such as fast-stabilizing intensity and insensitivity to temperature, and may contribute to developing medical devices capable of containing SARS-CoV-2 infection. By demonstrating SARS-CoV-2 inactivation with very short-term UVC-LED irradiation, our study may suggest guidelines for securing a safer medical environment.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: SARS-CoV-2 / COVID-19 Type of study: Experimental Studies / Prognostic study Topics: Vaccines Limits: Humans Language: English Journal: Sci Rep Year: 2022 Document Type: Article

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Full text: Available Collection: International databases Database: MEDLINE Main subject: SARS-CoV-2 / COVID-19 Type of study: Experimental Studies / Prognostic study Topics: Vaccines Limits: Humans Language: English Journal: Sci Rep Year: 2022 Document Type: Article