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Ligand-based drug repurposing strategy identified SARS-CoV-2 RNA G-quadruplex binders.
Moraca, Federica; Marzano, Simona; D'Amico, Francesco; Lupia, Antonio; Di Fonzo, Silvia; Vertecchi, Eleonora; Salvati, Erica; Di Porzio, Anna; Catalanotti, Bruno; Randazzo, Antonio; Pagano, Bruno; Amato, Jussara.
  • Moraca F; Department of Pharmacy, University of Naples Federico II, Via D. Montesano 49, 80131 Naples, Italy. bruno.pagano@unina.it.
  • Marzano S; Net4Science srl, University "Magna Græcia" of Catanzaro, 88100 Catanzaro, Italy.
  • D'Amico F; Department of Pharmacy, University of Naples Federico II, Via D. Montesano 49, 80131 Naples, Italy. bruno.pagano@unina.it.
  • Lupia A; Elettra-Sincrotrone Trieste S. C. p. A., Science Park, 34149 Trieste, Italy.
  • Di Fonzo S; Department of Pharmacy, University of Naples Federico II, Via D. Montesano 49, 80131 Naples, Italy. bruno.pagano@unina.it.
  • Vertecchi E; Net4Science srl, University "Magna Græcia" of Catanzaro, 88100 Catanzaro, Italy.
  • Salvati E; Elettra-Sincrotrone Trieste S. C. p. A., Science Park, 34149 Trieste, Italy.
  • Di Porzio A; Institute of Molecular Biology and Pathology, National Research Council, Via degli Apuli 4, 00185 Rome, Italy.
  • Catalanotti B; Institute of Molecular Biology and Pathology, National Research Council, Via degli Apuli 4, 00185 Rome, Italy.
  • Randazzo A; Department of Pharmacy, University of Naples Federico II, Via D. Montesano 49, 80131 Naples, Italy. bruno.pagano@unina.it.
  • Pagano B; Department of Pharmacy, University of Naples Federico II, Via D. Montesano 49, 80131 Naples, Italy. bruno.pagano@unina.it.
  • Amato J; Department of Pharmacy, University of Naples Federico II, Via D. Montesano 49, 80131 Naples, Italy. bruno.pagano@unina.it.
Chem Commun (Camb) ; 58(85): 11913-11916, 2022 Oct 25.
Article in English | MEDLINE | ID: covidwho-2050566
ABSTRACT
The single-stranded RNA genome of SARS-CoV-2 contains some G-quadruplex-forming G-rich elements which are putative drug targets. Here, we performed a ligand-based pharmacophore virtual screening of FDA approved drugs to find candidates targeting such RNA structures. Further in silico and in vitro assays identified three drugs as emerging SARS-CoV-2 RNA G-quadruplex binders.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Drug Repositioning / COVID-19 Drug Treatment Limits: Humans Language: English Journal: Chem Commun (Camb) Journal subject: Chemistry Year: 2022 Document Type: Article Affiliation country: D2cc03135c

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Drug Repositioning / COVID-19 Drug Treatment Limits: Humans Language: English Journal: Chem Commun (Camb) Journal subject: Chemistry Year: 2022 Document Type: Article Affiliation country: D2cc03135c