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Seroprevalence of SARS-CoV-2 in Mexican Health Care Workers after Two Years of the Pandemic: The Picture of an Ophthalmic Medical Centre.
Garfias, Yonathan; Magaña-Guerrero, Fátima Sofía; Buentello-Volante, Beatriz; Cruz Vega, Itayetzin Beurini; Islas-Castro, Ilse; Sánchez Cisneros, Paola de Jesús; Aguayo Flores, José Eduardo; Salas Lais, Angel Gustavo; Muñoz Medina, José Esteban; Mata-Haro, Verónica; Reséndiz-Sandoval, Mónica; Vázquez-García, Verónica A; Hernández, Jesús.
  • Garfias Y; Research Unit, Institute of Ophthalmology, Conde de Valenciana Foundation. Chimalpopoca, Mexico, Mexico.
  • Magaña-Guerrero FS; Department of Biochemistry, Faculty of Medicine, Universidad Nacional Autónoma de México, Mexico, Mexico.
  • Buentello-Volante B; Research Unit, Institute of Ophthalmology, Conde de Valenciana Foundation. Chimalpopoca, Mexico, Mexico.
  • Cruz Vega IB; Research Unit, Institute of Ophthalmology, Conde de Valenciana Foundation. Chimalpopoca, Mexico, Mexico.
  • Islas-Castro I; Research Unit, Institute of Ophthalmology, Conde de Valenciana Foundation. Chimalpopoca, Mexico, Mexico.
  • Sánchez Cisneros PJ; Research Unit, Institute of Ophthalmology, Conde de Valenciana Foundation. Chimalpopoca, Mexico, Mexico.
  • Aguayo Flores JE; Research Unit, Institute of Ophthalmology, Conde de Valenciana Foundation. Chimalpopoca, Mexico, Mexico.
  • Salas Lais AG; Research Unit, Institute of Ophthalmology, Conde de Valenciana Foundation. Chimalpopoca, Mexico, Mexico.
  • Muñoz Medina JE; Coordinación de Calidad de Insumos y Laboratorios Especializados, Instituto Mexicano del Seguro Social, IMSS, Ciudad de México, Mexico.
  • Mata-Haro V; Coordinación de Calidad de Insumos y Laboratorios Especializados, Instituto Mexicano del Seguro Social, Mexico City Mexico.
  • Reséndiz-Sandoval M; Laboratorio de Microbiología e Inmunología, Centro de Investigación en Alimentación y Desarrollo A. C. (CIAD), Hermosillo, Mexico.
  • Vázquez-García VA; Laboratorio de Inmunología, Centro de Investigación en Alimentación y Desarrollo, A.C. (CIAD), Hermosillo, Mexico.
  • Hernández J; Laboratorio de Inmunología, Centro de Investigación en Alimentación y Desarrollo, A.C. (CIAD), Hermosillo, Mexico.
Ophthalmic Epidemiol ; : 1-7, 2022 Oct 02.
Article in English | MEDLINE | ID: covidwho-2050888
ABSTRACT

OBJECTIVE:

In this study, we investigated the impact of the SARS-CoV-2 vaccination on seroprevalence in a cohort of healthcare workers (HCW) at an ophthalmic medical center.

METHODS:

IgG antibodies against the N, S1, and S2 antigens of SARS-CoV-2 as well as their serum neutralizing activity were determined.

RESULTS:

In the present study, we observed that 98.4% of HCW were seropositive for S1/S2 proteins of SARS-CoV-2 due to the national vaccination program. Interestingly, 78.4% of the participants had anti-N protein antibodies, suggesting previous COVID-19 infection. We also evaluated the neutralizing antibodies and found that the mean value was high (90.7%).

CONCLUSION:

These results indicate that our HCWs cohort presented a robust hybrid humoral response owing to the massive national vaccination program and natural infections.
Keywords

Full text: Available Collection: International databases Database: MEDLINE Type of study: Cohort study / Experimental Studies / Observational study / Prognostic study Topics: Vaccines Country/Region as subject: Mexico Language: English Journal: Ophthalmic Epidemiol Journal subject: Epidemiology / Ophthalmology Year: 2022 Document Type: Article Affiliation country: 09286586.2022.2127789

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Full text: Available Collection: International databases Database: MEDLINE Type of study: Cohort study / Experimental Studies / Observational study / Prognostic study Topics: Vaccines Country/Region as subject: Mexico Language: English Journal: Ophthalmic Epidemiol Journal subject: Epidemiology / Ophthalmology Year: 2022 Document Type: Article Affiliation country: 09286586.2022.2127789