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Memory B cell responses to Omicron subvariants after SARS-CoV-2 mRNA breakthrough infection in humans.
Wang, Zijun; Zhou, Pengcheng; Muecksch, Frauke; Cho, Alice; Ben Tanfous, Tarek; Canis, Marie; Witte, Leander; Johnson, Brianna; Raspe, Raphael; Schmidt, Fabian; Bednarski, Eva; Da Silva, Justin; Ramos, Victor; Zong, Shuai; Turroja, Martina; Millard, Katrina G; Yao, Kai-Hui; Shimeliovich, Irina; Dizon, Juan; Kaczynska, Anna; Jankovic, Mila; Gazumyan, Anna; Oliveira, Thiago Y; Caskey, Marina; Gaebler, Christian; Bieniasz, Paul D; Hatziioannou, Theodora; Nussenzweig, Michel C.
  • Wang Z; Laboratory of Molecular Immunology, The Rockefeller University, New York, NY.
  • Zhou P; Laboratory of Molecular Immunology, The Rockefeller University, New York, NY.
  • Muecksch F; Laboratory of Retrovirology, The Rockefeller University, New York, NY.
  • Cho A; Laboratory of Molecular Immunology, The Rockefeller University, New York, NY.
  • Ben Tanfous T; Laboratory of Molecular Immunology, The Rockefeller University, New York, NY.
  • Canis M; Laboratory of Retrovirology, The Rockefeller University, New York, NY.
  • Witte L; Laboratory of Retrovirology, The Rockefeller University, New York, NY.
  • Johnson B; Laboratory of Molecular Immunology, The Rockefeller University, New York, NY.
  • Raspe R; Laboratory of Molecular Immunology, The Rockefeller University, New York, NY.
  • Schmidt F; Laboratory of Retrovirology, The Rockefeller University, New York, NY.
  • Bednarski E; Laboratory of Retrovirology, The Rockefeller University, New York, NY.
  • Da Silva J; Laboratory of Retrovirology, The Rockefeller University, New York, NY.
  • Ramos V; Laboratory of Molecular Immunology, The Rockefeller University, New York, NY.
  • Zong S; Laboratory of Molecular Immunology, The Rockefeller University, New York, NY.
  • Turroja M; Laboratory of Molecular Immunology, The Rockefeller University, New York, NY.
  • Millard KG; Laboratory of Molecular Immunology, The Rockefeller University, New York, NY.
  • Yao KH; Laboratory of Molecular Immunology, The Rockefeller University, New York, NY.
  • Shimeliovich I; Laboratory of Molecular Immunology, The Rockefeller University, New York, NY.
  • Dizon J; Laboratory of Molecular Immunology, The Rockefeller University, New York, NY.
  • Kaczynska A; Laboratory of Molecular Immunology, The Rockefeller University, New York, NY.
  • Jankovic M; Laboratory of Molecular Immunology, The Rockefeller University, New York, NY.
  • Gazumyan A; Laboratory of Molecular Immunology, The Rockefeller University, New York, NY.
  • Oliveira TY; Laboratory of Molecular Immunology, The Rockefeller University, New York, NY.
  • Caskey M; Laboratory of Molecular Immunology, The Rockefeller University, New York, NY.
  • Gaebler C; Laboratory of Molecular Immunology, The Rockefeller University, New York, NY.
  • Bieniasz PD; Laboratory of Retrovirology, The Rockefeller University, New York, NY.
  • Hatziioannou T; Howard Hughes Medical Institute, Chevy Chase, MD.
  • Nussenzweig MC; Laboratory of Retrovirology, The Rockefeller University, New York, NY.
J Exp Med ; 219(12)2022 12 05.
Article in English | MEDLINE | ID: covidwho-2051192
ABSTRACT
Individuals who receive a third mRNA vaccine dose show enhanced protection against severe COVID-19, but little is known about the impact of breakthrough infections on memory responses. Here, we examine the memory antibodies that develop after a third or fourth antigenic exposure by Delta or Omicron BA.1 infection, respectively. A third exposure to antigen by Delta breakthrough increases the number of memory B cells that produce antibodies with comparable potency and breadth to a third mRNA vaccine dose. A fourth antigenic exposure with Omicron BA.1 infection increased variant-specific plasma antibody and memory B cell responses. However, the fourth exposure did not increase the overall frequency of memory B cells or their general potency or breadth compared to a third mRNA vaccine dose. In conclusion, a third antigenic exposure by Delta infection elicits strain-specific memory responses and increases in the overall potency and breadth of the memory B cells. In contrast, the effects of a fourth antigenic exposure with Omicron BA.1 are limited to increased strain-specific memory with little effect on the potency or breadth of memory B cell antibodies. The results suggest that the effect of strain-specific boosting on memory B cell compartment may be limited.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: SARS-CoV-2 / COVID-19 Topics: Vaccines / Variants Limits: Humans Language: English Year: 2022 Document Type: Article

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Full text: Available Collection: International databases Database: MEDLINE Main subject: SARS-CoV-2 / COVID-19 Topics: Vaccines / Variants Limits: Humans Language: English Year: 2022 Document Type: Article