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Coronavirus Disease 2019 (COVID-19) Severity Among Women of Reproductive Age With Symptomatic Laboratory-Confirmed Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Infection by Pregnancy Status-United States, 1 January 2020-25 December 2021.
Strid, Penelope; Zapata, Lauren B; Tong, Van T; Zambrano, Laura D; Woodworth, Kate R; Riser, Aspen P; Galang, Romeo R; Gilboa, Suzanne M; Ellington, Sascha R.
  • Strid P; Epidemiology Task Force, Pregnancy and Infant Linked Outcomes Team, COVID-19 Emergency Response, Centers for Disease Control and Prevention, Atlanta, Georgia, USA.
  • Zapata LB; Epidemiology Task Force, Pregnancy and Infant Linked Outcomes Team, COVID-19 Emergency Response, Centers for Disease Control and Prevention, Atlanta, Georgia, USA.
  • Tong VT; Epidemiology Task Force, Pregnancy and Infant Linked Outcomes Team, COVID-19 Emergency Response, Centers for Disease Control and Prevention, Atlanta, Georgia, USA.
  • Zambrano LD; Epidemiology Task Force, Pregnancy and Infant Linked Outcomes Team, COVID-19 Emergency Response, Centers for Disease Control and Prevention, Atlanta, Georgia, USA.
  • Woodworth KR; Epidemiology Task Force, Pregnancy and Infant Linked Outcomes Team, COVID-19 Emergency Response, Centers for Disease Control and Prevention, Atlanta, Georgia, USA.
  • Riser AP; Epidemiology Task Force, Pregnancy and Infant Linked Outcomes Team, COVID-19 Emergency Response, Centers for Disease Control and Prevention, Atlanta, Georgia, USA.
  • Galang RR; Epidemiology Task Force, Pregnancy and Infant Linked Outcomes Team, COVID-19 Emergency Response, Centers for Disease Control and Prevention, Atlanta, Georgia, USA.
  • Gilboa SM; Epidemiology Task Force, Pregnancy and Infant Linked Outcomes Team, COVID-19 Emergency Response, Centers for Disease Control and Prevention, Atlanta, Georgia, USA.
  • Ellington SR; Epidemiology Task Force, Pregnancy and Infant Linked Outcomes Team, COVID-19 Emergency Response, Centers for Disease Control and Prevention, Atlanta, Georgia, USA.
Clin Infect Dis ; 75(Supplement_2): S317-S325, 2022 Oct 03.
Article in English | MEDLINE | ID: covidwho-2051344
ABSTRACT

BACKGROUND:

Information on the severity of coronavirus disease 2019 (COVID-19) attributable to the Delta variant in the United States among pregnant people is limited. We assessed the risk for severe COVID-19 by pregnancy status in the period of Delta variant predominance compared with the pre-Delta period.

METHODS:

Laboratory-confirmed severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infections among symptomatic women of reproductive age (WRA) were assessed. We calculated adjusted risk ratios for severe disease including intensive care unit (ICU) admission, receipt of invasive ventilation or extracorporeal membrane oxygenation (ECMO), and death comparing the pre-Delta period (1 January 2020-26 June 2021) and the Delta period (27 June 2021-25 December 2021) for pregnant and nonpregnant WRA.

RESULTS:

Compared with the pre-Delta period, the risk of ICU admission during the Delta period was 41% higher (adjusted risk ratio [aRR], 1.41 [95% confidence interval {CI}, 1.17-1.69]) for pregnant WRA and 9% higher (aRR, 1.09 [95% CI, 1.00-1.18]) for nonpregnant WRA. The risk of invasive ventilation or ECMO was higher for pregnant (aRR, 1.83 [95% CI, 1.26-2.65]) and nonpregnant (aRR, 1.34 [95% CI, 1.17-1.54]) WRA in the Delta period. During the Delta period, the risk of death was 3.33 (95% CI, 2.48-4.46) times the risk in the pre-Delta period among pregnant WRA and 1.62 (95% CI, 1.49-1.77) among nonpregnant WRA.

CONCLUSIONS:

Compared with the pre-Delta period, pregnant and nonpregnant WRA were at increased risk for severe COVID-19 in the Delta period.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Pregnancy Complications, Infectious / COVID-19 Type of study: Observational study / Prognostic study Topics: Variants Limits: Female / Humans / Pregnancy Country/Region as subject: North America Language: English Journal: Clin Infect Dis Journal subject: Communicable Diseases Year: 2022 Document Type: Article Affiliation country: Cid

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Pregnancy Complications, Infectious / COVID-19 Type of study: Observational study / Prognostic study Topics: Variants Limits: Female / Humans / Pregnancy Country/Region as subject: North America Language: English Journal: Clin Infect Dis Journal subject: Communicable Diseases Year: 2022 Document Type: Article Affiliation country: Cid