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Effectiveness of Coronavirus Disease 2019 (COVID-19) mRNA Vaccines Against Infection During an Outbreak of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Beta (B.1.351) Variant in a Skilled Nursing Facility: Virginia, March-April 2021.
Moline, Heidi L; Keaton, Amelia; Rice, Whitney; Varghese, Jasmine; Deng, Li; Waters, Ansley; Barringer, Anna; Winston, Devonne; Fields, Virgie; Slifka, Kara Jacobs; Verani, Jennifer R; Schrag, Stephanie J; Jernigan, John; Tate, Jacqueline E; Fleming-Dutra, Katherine E.
  • Moline HL; COVID-19 Response Team, Centers for Disease Control and Prevention, Atlanta, Georgia, USA.
  • Keaton A; Epidemic Intelligence Service, Centers for Disease Control and Prevention, Atlanta, Georgia, USA.
  • Rice W; COVID-19 Response Team, Centers for Disease Control and Prevention, Atlanta, Georgia, USA.
  • Varghese J; Virginia Beach Health Department, Virginia Beach, Virginia, USA.
  • Deng L; COVID-19 Response Team, Centers for Disease Control and Prevention, Atlanta, Georgia, USA.
  • Waters A; COVID-19 Response Team, Centers for Disease Control and Prevention, Atlanta, Georgia, USA.
  • Barringer A; Council of State and Territorial Epidemiologists,, Atlanta, GA, USA.
  • Winston D; Virginia Department of Health, Richmond, Virginia, USA.
  • Fields V; Virginia Beach Health Department, Virginia Beach, Virginia, USA.
  • Slifka KJ; Virginia Beach Health Department, Virginia Beach, Virginia, USA.
  • Verani JR; Virginia Department of Health, Richmond, Virginia, USA.
  • Schrag SJ; COVID-19 Response Team, Centers for Disease Control and Prevention, Atlanta, Georgia, USA.
  • Jernigan J; COVID-19 Response Team, Centers for Disease Control and Prevention, Atlanta, Georgia, USA.
  • Tate JE; COVID-19 Response Team, Centers for Disease Control and Prevention, Atlanta, Georgia, USA.
  • Fleming-Dutra KE; COVID-19 Response Team, Centers for Disease Control and Prevention, Atlanta, Georgia, USA.
Clin Infect Dis ; 75(Supplement_2): S155-S158, 2022 Oct 03.
Article in English | MEDLINE | ID: covidwho-2051356
ABSTRACT
In April 2021, we assessed mRNA vaccine effectiveness (VE) in the context of a COVID-19 outbreak in a skilled nursing facility. Among 28 cases, genomic sequencing was performed on 4 specimens on 4 different patients, and all were classified by sequence analysis as the Beta (B.1.351) variant. Adjusted VE among residents was 65% (95% confidence interval 25-84%). These findings underscore the importance of vaccination for prevention of COVID-19 in skilled nursing facilities.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: SARS-CoV-2 / COVID-19 Type of study: Experimental Studies / Observational study Topics: Vaccines / Variants Limits: Humans Country/Region as subject: North America Language: English Journal: Clin Infect Dis Journal subject: Communicable Diseases Year: 2022 Document Type: Article Affiliation country: Cid

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Full text: Available Collection: International databases Database: MEDLINE Main subject: SARS-CoV-2 / COVID-19 Type of study: Experimental Studies / Observational study Topics: Vaccines / Variants Limits: Humans Country/Region as subject: North America Language: English Journal: Clin Infect Dis Journal subject: Communicable Diseases Year: 2022 Document Type: Article Affiliation country: Cid