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Outcomes of coronavirus disease 19 patients with a history of rheumatoid arthritis: A retrospective registry-based study in Iran.
Zargaran, Mahsa; Movassaghi, Shafieh; Seyyedsalehi, Monireh Sadat; Zendehdel, Kazem; Rostamian, Abdolrahman.
  • Zargaran M; Department of Internal Medicine, Imam Khomeini Hospital, Tehran University of Medical Sciences, Tehran, Iran.
  • Movassaghi S; Department of Rheumatology, Imam Khomeini Hospital, Tehran University of Medical Sciences, Tehran, Iran.
  • Seyyedsalehi MS; Cancer Research Center, Cancer Institute, Tehran University of Medical Sciences, Tehran, Iran.
  • Zendehdel K; Cancer Research Center, Cancer Institute, Tehran University of Medical Sciences, Tehran, Iran.
  • Rostamian A; Department of Rheumatology, Imam Khomeini Hospital, Tehran University of Medical Sciences, Tehran, Iran.
Int J Rheum Dis ; 25(10): 1196-1199, 2022 Oct.
Article in English | MEDLINE | ID: covidwho-2052166
ABSTRACT

BACKGROUND:

We aimed to study the outcomes of coronavirus disease 2019 (COVID-19) in patients with a history of rheumatoid arthritis (RA) in Iran, where most patients receive corticosteroids and are at high risk for COVID-19 infection.

METHOD:

We collected the demographic, diagnostic, and treatment data of all COVID-19 patients by the clinical COVID-19 registry system. We recruited 38 RA patients and 2216 non-RA patients from the COVID-19 registry. The primary outcome was mortality due to COVID-19. We also studied the risk of intensive care unit admission and intubation in RA patients compared to non-RA patients. We used multiple logistic regression analysis to study the association between RA and the risk of COVID-19 outcomes.

RESULT:

We recruited 38 RA patients and 2216 non-RA patients from the COVID-19 registry. The RA patients had a higher mean age (59.9 years) than the non-RA patients (57.7 years). The group of RA patients had a larger proportion of women (76.3%) than the non-RA patients (40.8%). The death rate due to COVID-19 was significantly higher in RA patients than non-RA patients (odds ratio [OR] = 2.69, 95% confidence interval [CI] = 1.24-5.81). The OR was higher among those who received prednisolone than among those who did not (OR = 3.59, 95% CI = 1.54-7.81). The odds of intubation were statistically significant among patients who received corticosteroid therapy (OR = 2.58, 95% CI = 1.07-6.18).

CONCLUSION:

The risk of COVID-19 outcomes was higher in RA patients than non-RA patients, especially for RA patients who received a low dose of prednisolone. The results of this study can be used to triage RA patients who get infected by COVID-19. Further studies with larger sample sizes are required to more precisely define the high-risk groups.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Arthritis, Rheumatoid / COVID-19 Type of study: Diagnostic study / Experimental Studies / Observational study / Prognostic study / Randomized controlled trials Limits: Female / Humans / Middle aged Country/Region as subject: Asia Language: English Journal: Int J Rheum Dis Journal subject: Rheumatology Year: 2022 Document Type: Article Affiliation country: 1756-185x.14405

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Arthritis, Rheumatoid / COVID-19 Type of study: Diagnostic study / Experimental Studies / Observational study / Prognostic study / Randomized controlled trials Limits: Female / Humans / Middle aged Country/Region as subject: Asia Language: English Journal: Int J Rheum Dis Journal subject: Rheumatology Year: 2022 Document Type: Article Affiliation country: 1756-185x.14405