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Scientific evaluation of alleged findings in HPV vaccines: Molecular mimicry and mouse models of vaccine-induced disease.
Matsumura, Noriomi; Tsunoda, Ikuo.
  • Matsumura N; Department of Obstetrics and Gynecology, Kindai University Faculty of Medicine, Osaka, Japan.
  • Tsunoda I; Department of Microbiology, Kindai University Faculty of Medicine, Osaka, Japan.
Cancer Sci ; 113(10): 3313-3320, 2022 Oct.
Article in English | MEDLINE | ID: covidwho-2052328
ABSTRACT
Cervical cancer is caused by infections of the human papillomavirus (HPV), which can be prevented by vaccinations. In Japan, although about 3000 people die of cervical cancer annually, the HPV vaccination rate has remained extremely low in the eligible population since many Japanese have been concerned that "diverse symptoms," such as chronic pain, movement disorders, and cognitive impairment, may occur as adverse reactions after HPV vaccination. The concern has been raised by media coverage of the ongoing HPV vaccine lawsuits, in which the plaintiffs complained of their symptoms caused by HPV vaccination. The claims have been based on the alleged pathogenic findings in research articles on HPV vaccines, summarized in the document prepared by the plaintiffs' attorneys. We critically evaluated these articles, in which the authors proposed the following findings/

hypothesis:

(i) molecular mimicry between HPV L1 and human proteins leads to the production of cross-reactive antibodies; and (ii) HPV vaccine injection in mice causes damage in the brain, a mouse model for HPV vaccine associated neuro-immunopathic syndrome (HANS). We found that these hypotheses were based mainly on the findings from a few research groups and that all the articles had flaws in the method, result, or discussion sections. Our current evaluation should help better understand the validity of the findings, which have been often misunderstood as the truth by the general public. We propose to accumulate high-quality data on potential adverse events following HPV vaccination and to continue critically evaluating them.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Uterine Cervical Neoplasms / Papillomavirus Infections / Alphapapillomavirus / Papillomavirus Vaccines Type of study: Experimental Studies / Observational study / Randomized controlled trials Topics: Vaccines Limits: Animals / Female / Humans Language: English Journal: Cancer Sci Year: 2022 Document Type: Article Affiliation country: Cas.15482

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Uterine Cervical Neoplasms / Papillomavirus Infections / Alphapapillomavirus / Papillomavirus Vaccines Type of study: Experimental Studies / Observational study / Randomized controlled trials Topics: Vaccines Limits: Animals / Female / Humans Language: English Journal: Cancer Sci Year: 2022 Document Type: Article Affiliation country: Cas.15482