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Characteristics of Ocular Findings of Patients With Coronavirus Disease 2019 (COVID-19) in Hubei Province, China.
Wu, Ping; Duan, Fang; Luo, Chunhua; Liu, Qiang; Qu, Xingguang; Liang, Liang; Wu, Kaili.
  • Wu P; Department of Ophthalmology, The First College of Clinical Medical Science, Yichang Central People's Hospital, China Three Gorges University, Yichang, China.
  • Duan F; Zhongshan Ophthalmic Center, State Key Laboratory of Ophthalmology, Sun Yat-Sen University, Guangzhou, China.
  • Luo C; Department of Ophthalmology, The First College of Clinical Medical Science, Yichang Central People's Hospital, China Three Gorges University, Yichang, China.
  • Liu Q; Department of Ophthalmology, The First College of Clinical Medical Science, Yichang Central People's Hospital, China Three Gorges University, Yichang, China.
  • Qu X; Department of Ophthalmology, The First College of Clinical Medical Science, Yichang Central People's Hospital, China Three Gorges University, Yichang, China.
  • Liang L; Department of Ophthalmology, The First College of Clinical Medical Science, Yichang Central People's Hospital, China Three Gorges University, Yichang, China.
  • Wu K; Zhongshan Ophthalmic Center, State Key Laboratory of Ophthalmology, Sun Yat-Sen University, Guangzhou, China.
JAMA Ophthalmol ; 138(5): 575-578, 2020 May 01.
Article in English | MEDLINE | ID: covidwho-20527
Semantic information from SemMedBD (by NLM)
1. COVID-19 PROCESS_OF Patients
Subject
COVID-19
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PROCESS_OF
Object
Patients
2. Infected PROCESS_OF Persons
Subject
Infected
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PROCESS_OF
Object
Persons
3. COVID-19 COEXISTS_WITH 2019 novel coronavirus
Subject
COVID-19
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COEXISTS_WITH
Object
2019 novel coronavirus
4. conjunctiva PART_OF Patients
Subject
conjunctiva
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Patients
5. conjunctiva LOCATION_OF 2019 novel coronavirus
Subject
conjunctiva
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Object
2019 novel coronavirus
6. Positive Finding PROCESS_OF Patients
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Positive Finding
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PROCESS_OF
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Patients
7. Eye LOCATION_OF Symptoms
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Eye
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LOCATION_OF
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Symptoms
8. Symptoms PROCESS_OF Patients
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Predicate
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Patients
9. COVID-19 OCCURS_IN Patients
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OCCURS_IN
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Patients
10. COVID-19 PROCESS_OF Patients
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Predicate
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11. Infected PROCESS_OF Persons
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12. COVID-19 COEXISTS_WITH 2019 novel coronavirus
Subject
COVID-19
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COEXISTS_WITH
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2019 novel coronavirus
13. conjunctiva PART_OF Patients
Subject
conjunctiva
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PART_OF
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Patients
14. conjunctiva LOCATION_OF 2019 novel coronavirus
Subject
conjunctiva
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LOCATION_OF
Object
2019 novel coronavirus
15. Positive Finding PROCESS_OF Patients
Subject
Positive Finding
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PROCESS_OF
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Patients
16. Eye LOCATION_OF Symptoms
Subject
Eye
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LOCATION_OF
Object
Symptoms
17. Symptoms PROCESS_OF Patients
Subject
Symptoms
Predicate
PROCESS_OF
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Patients
18. COVID-19 OCCURS_IN Patients
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COVID-19
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OCCURS_IN
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ABSTRACT
IMPORTANCE While the outbreak of coronavirus disease 2019 (COVID-19) has resulted in more than 100 000 infected individuals in China and worldwide, there are few reports on the association of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) with ocular abnormalities. Understanding ocular manifestations of patients with COVID-19 by ophthalmologists and others may facilitate the diagnosis and prevention of transmission of the disease.

OBJECTIVE:

To investigate ocular manifestations and viral prevalence in the conjunctiva of patients with COVID-19. DESIGN, SETTING, AND

PARTICIPANTS:

In this case series, patients with COVID-19 treated from February 9 to 15, 2020, at a hospital center in Hubei province, China, were retrospectively reviewed for ocular manifestations. During the period of treatment, the ocular signs and symptoms as well as results of blood tests and reverse transcriptase-polymerase chain reaction (RT-PCR) from nasopharyngeal and conjunctival swabs for SARS-CoV-2 were noted and analyzed. MAIN OUTCOMES AND

MEASURES:

Ocular signs and symptoms as well as results of blood tests and RT-PCR for SARS-CoV-2.

RESULTS:

Of the 38 included patients with clinically confirmed COVID-19, 25 (65.8%) were male, and the mean (SD) age was 65.8 (16.6) years. Among them, 28 patients (73.7%) had positive findings for COVID-19 on RT-PCR from nasopharyngeal swabs, and of these, 2 patients (5.2%) yielded positive findings for SARS-CoV-2 in their conjunctival as well as nasopharyngeal specimens. A total of 12 of 38 patients (31.6%; 95% CI, 17.5-48.7) had ocular manifestations consistent with conjunctivitis, including conjunctival hyperemia, chemosis, epiphora, or increased secretions. By univariate analysis, patients with ocular symptoms were more likely to have higher white blood cell and neutrophil counts and higher levels of procalcitonin, C-reactive protein, and lactate dehydrogenase than patients without ocular symptoms. In addition, 11 of 12 patients with ocular abnormalities (91.7%; 95% CI, 61.5-99.8) had positive results for SARS-CoV-2 on RT-PCR from nasopharyngeal swabs. Of these, 2 (16.7%) had positive results for SARS-CoV-2 on RT-PCR from both conjunctival and nasopharyngeal swabs. CONCLUSIONS AND RELEVANCE In this study, one-third of patients with COVID-19 had ocular abnormalities, which frequently occurred in patients with more severe COVID-19. Although there is a low prevalence of SARS-CoV-2 in tears, it is possible to transmit via the eyes.
Subject(s)

Full text: Available Collection: International databases Database: MEDLINE Main subject: Pneumonia, Viral / RNA, Viral / Coronavirus Infections / Disease Transmission, Infectious / Conjunctiva / Eye Diseases / Betacoronavirus Type of study: Diagnostic study / Observational study / Prognostic study / Risk factors Limits: Aged / Female / Humans / Male Country/Region as subject: Asia Language: English Journal: JAMA Ophthalmol Year: 2020 Document Type: Article Affiliation country: Jamaophthalmol.2020.1291

Full text: Available Collection: International databases Database: MEDLINE Main subject: Pneumonia, Viral / RNA, Viral / Coronavirus Infections / Disease Transmission, Infectious / Conjunctiva / Eye Diseases / Betacoronavirus Type of study: Diagnostic study / Observational study / Prognostic study / Risk factors Limits: Aged / Female / Humans / Male Country/Region as subject: Asia Language: English Journal: JAMA Ophthalmol Year: 2020 Document Type: Article Affiliation country: Jamaophthalmol.2020.1291