Molecular characterization of a novel recombinant lumpy skin disease virus isolated during an outbreak in Tyumen, Russia, in 2019.
Transbound Emerg Dis
; 69(5): e2312-e2317, 2022 Sep.
Article
in English
| MEDLINE | ID: covidwho-2053014
ABSTRACT
Lumpy skin disease virus causes a debilitating pox disease of domesticated cattle and water buffalos. In the last decade, LSDV has spread from Africa into the Middle East, Europe and most recently Asia. As of 2017, atypical outbreaks caused by novel LSDV strains were reported in Russia, followed by China and Vietnam between 2018 and 2020. In this work, we describe another unique recombinant LSDV strain recovered from Tyumen, Russia in 2019. Typing of the virus using currently available qPCR protocols produced inconclusive results and subsequently the complete genome of the isolate was determined. The consensus genome contained statistically significant signals of possible recombination events between parental strains KSGPO-240/Kenya/1958 and the live attenuated vaccine LW/1958. The novel strain carries 25 unique breakpoints different from the known recombinant strains. Additionally, the findings reiterate the importance of complete genome sequencing when analysing outbreak samples caused in particular by mosaic LSDV, in contrast to only performing specified qPCRs.
Keywords
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Main subject:
Cattle Diseases
/
Lumpy Skin Disease
/
Lumpy skin disease virus
Type of study:
Observational study
Topics:
Vaccines
Limits:
Animals
Country/Region as subject:
Africa
/
Asia
/
Europa
Language:
English
Journal:
Transbound Emerg Dis
Journal subject:
Veterinary Medicine
Year:
2022
Document Type:
Article
Affiliation country:
Tbed.14574
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