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Comparing the expression levels of tripartite motif containing 28 in mild and severe COVID-19 infection.
Tavakoli, Rezvan; Rahimi, Pooneh; Hamidi-Fard, Mojtaba; Eybpoosh, Sana; Doroud, Delaram; Ahmadi, Iraj; Anvari, Enayat; Aghasadeghi, Mohammadreza; Fateh, Abolfazl.
  • Tavakoli R; Hepatitis and AIDS Department, Pasteur Institute of Iran, Tehran, Iran.
  • Rahimi P; Hepatitis and AIDS Department, Pasteur Institute of Iran, Tehran, Iran.
  • Hamidi-Fard M; Viral Vaccine Research Center, Pasteur Institute of Iran, Tehran, Iran.
  • Eybpoosh S; Hepatitis and AIDS Department, Pasteur Institute of Iran, Tehran, Iran.
  • Doroud D; Viral Vaccine Research Center, Pasteur Institute of Iran, Tehran, Iran.
  • Ahmadi I; Department of Epidemiology and Biostatistics, Research Centre for Emerging and Reemerging Infectious Diseases, Pasteur Institute of Iran, Tehran, Iran.
  • Anvari E; Quality Control Department, Production and Research Complex, Pasteur institute of Iran, Tehran, Iran.
  • Aghasadeghi M; Department of Physiology, School of Medicine, Ilam University of Medical Science, Ilam, Iran.
  • Fateh A; Department of Physiology, School of Medicine, Ilam University of Medical Science, Ilam, Iran.
Virol J ; 19(1): 156, 2022 10 03.
Article in English | MEDLINE | ID: covidwho-2053925
ABSTRACT

BACKGROUND:

Tripartite motif-containing 28 (TRIM28) is an impressive regulator of the epigenetic control of the antiviral immune response. This study evaluated if the differential expression of TRIM28 correlates with the severity of coronavirus disease 2019 (COVID-19) infection.

METHODS:

A total of 330 COVID-19 patients, including 188 mild and 142 severe infections, and 160 healthy controls were enrolled in this study. Quantitative real-time polymerase chain reaction (qPCR) was used to determine the expression levels of TRIM28 in the studied patients.

RESULTS:

TRIM28 mRNA levels were significantly lower in both groups of patients versus the control group and in the severe group indicated further reduction in comparison to mild infection. The multivariate logistic regression analysis showed the mean age, lower levels of low-density lipoprotein (LDL), high-density lipoprotein (HDL), cholesterol, lower 25-hydroxyvitamin D, and PCR cycle threshold (Ct) value and higher levels of erythrocyte sedimentation rate (ESR) and differential expression of TRIM28 were linked to the severity of COVID-19 infection.

CONCLUSION:

The results of this study proved that the downregulation of TRIM28 might be associated with the severity of COVID-19 infection. Further studies are required to determine the association between the COVID-19 infection severity and TRIM family proteins.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: COVID-19 Type of study: Experimental Studies / Prognostic study / Randomized controlled trials Limits: Humans Language: English Journal: Virol J Journal subject: Virology Year: 2022 Document Type: Article Affiliation country: S12985-022-01885-0

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Full text: Available Collection: International databases Database: MEDLINE Main subject: COVID-19 Type of study: Experimental Studies / Prognostic study / Randomized controlled trials Limits: Humans Language: English Journal: Virol J Journal subject: Virology Year: 2022 Document Type: Article Affiliation country: S12985-022-01885-0