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SARS-CoV-2 and the pancreas: What do we know about acute pancreatitis in COVID-19 positive patients?
Brisinda, Giuseppe; Chiarello, Maria Michela; Tropeano, Giuseppe; Altieri, Gaia; Puccioni, Caterina; Fransvea, Pietro; Bianchi, Valentina.
  • Brisinda G; Department of Medical and Surgical Sciences, Fondazione Policlinico Universitario A Gemelli IRCCS, Rome 00168, Italy.
  • Chiarello MM; Department of Medicine and Surgery, Università Cattolica del Sacro Cuore, Rome 00168, Italy. gbrisin@tin.it.
  • Tropeano G; Department of Surgery, Azienda Sanitaria Provinciale di Cosenza, Cosenza 87100, Italy.
  • Altieri G; Emergency Surgery and Trauma Center, Fondazione Policlinico Universitario A Gemelli IRCCS, Rome 00168, Italy.
  • Puccioni C; Emergency Surgery and Trauma Center, Fondazione Policlinico Universitario A Gemelli IRCCS, Rome 00168, Italy.
  • Fransvea P; Emergency Surgery and Trauma Center, Fondazione Policlinico Universitario A Gemelli IRCCS, Rome 00168, Italy.
  • Bianchi V; Emergency Surgery and Trauma Center, Fondazione Policlinico Universitario A Gemelli IRCCS, Rome 00168, Italy.
World J Gastroenterol ; 28(36): 5240-5249, 2022 Sep 28.
Article in English | MEDLINE | ID: covidwho-2055461
ABSTRACT
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) can cause pancreatic damage, both directly to the pancreas via angiotensin-converting enzyme 2 receptors (the transmembrane proteins required for SARS-CoV-2 entry, which are highly expressed by pancreatic cells) and indirectly through locoregional vasculitis and thrombosis. Despite that, there is no clear evidence that SARS-CoV-2 is an etiological agent of acute pancreatitis. Acute pancreatitis in coronavirus disease 2019 (COVID-19) positive patients often recognizes biliary or alcoholic etiology. The prevalence of acute pancreatitis in COVID-19 positive patients is not exactly known. However, COVID-19 positive patients with acute pancreatitis have a higher mortality and an increased risk of intensive care unit admission and necrosis compared to COVID-19 negative patients. Acute respiratory distress syndrome is the most frequent cause of death in COVID-19 positive patients and concomitant acute pancreatitis. In this article, we reported recent evidence on the correlation between COVID-19 infection and acute pancreatitis.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Pancreatitis / COVID-19 Type of study: Diagnostic study / Etiology study / Observational study / Prognostic study Topics: Long Covid Limits: Humans Language: English Journal: World J Gastroenterol Journal subject: Gastroenterology Year: 2022 Document Type: Article Affiliation country: Wjg.v28.i36.5240

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Pancreatitis / COVID-19 Type of study: Diagnostic study / Etiology study / Observational study / Prognostic study Topics: Long Covid Limits: Humans Language: English Journal: World J Gastroenterol Journal subject: Gastroenterology Year: 2022 Document Type: Article Affiliation country: Wjg.v28.i36.5240