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Immune Response to SARS-CoV-2 Third Vaccine in Patients With Rheumatoid Arthritis Who Had No Seroconversion After Primary 2-Dose Regimen With Inactivated or Vector-Based Vaccines.
Isnardi, Carolina A; Cerda, Osvaldo L; Landi, Margarita; Cruces, Leonel; Schneeberger, Emilce E; Montoro, Claudia Calle; Alfaro, María Agustina; Roldán, Brian M; Gómez Vara, Andrea B; Giorgis, Pamela; Ezquer, Roberto Alejandro; Crespo Rocha, María G; Reyes Gómez, Camila R; de Los Ángeles Correa, Mária; Rosemffet, Marcos G; Abarza, Virginia Carrizo; Pellet, Santiago Catalan; Perandones, Miguel; Reimundes, Cecilia; Longueira, Yesica; Turk, Gabriela; Quiroga, María Florencia; Laufer, Natalia; Quintana, Rosana; de la Vega, María Celina; Kreplak, Nicolás; Pifano, Marina; Maid, Pablo; Pons-Estel, Guillermo J; Citera, Gustavo.
  • Isnardi CA; C.A. Isnardi, MD, Research Unit - Argentine Society of Rheumatology, and Instituto de Rehabilitación Psicofísica, Rheumatology Section.
  • Cerda OL; O.L. Cerda, MD, E.E. Schneeberger, MD, M.A. Alfaro, MD, B.M. Roldán, MD, A.B. Gómez Vara, MD, P. Giorgis, MD, R.A. Ezquer, MD, M.G. Crespo Rocha, MD, C.R. Reyes Gómez, MD, M.Á. Correa, MD, M.G. Rosemffet, MD, V.C. Abarza, MD, M. Perandones, MD, G. Citera, MD, Instituto de Rehabilitación Psicofísica,
  • Landi M; M. Landi, MD, C. Calle Montoro, MD, S. Catalan Pellet, MD, C. Reimundes, MD, P. Maid, MD, Austral University Hospital, Rheumatology Department.
  • Cruces L; L. Cruces, BCh, Y. Longueira, MSc, G. Turk, PhD, M.F. Quiroga, PhD, N. Laufer, MD, PhD, Universidad de Buenos Aires, Consejo Nacional de Investigaciones Científicas y Técnicas, Instituto de Investigaciones Biomédicas en Retrovirus y Sida (INBIRS), Facultad de Medicina, Ciudad Autónoma de Buenos Aire
  • Schneeberger EE; O.L. Cerda, MD, E.E. Schneeberger, MD, M.A. Alfaro, MD, B.M. Roldán, MD, A.B. Gómez Vara, MD, P. Giorgis, MD, R.A. Ezquer, MD, M.G. Crespo Rocha, MD, C.R. Reyes Gómez, MD, M.Á. Correa, MD, M.G. Rosemffet, MD, V.C. Abarza, MD, M. Perandones, MD, G. Citera, MD, Instituto de Rehabilitación Psicofísica,
  • Montoro CC; M. Landi, MD, C. Calle Montoro, MD, S. Catalan Pellet, MD, C. Reimundes, MD, P. Maid, MD, Austral University Hospital, Rheumatology Department.
  • Alfaro MA; O.L. Cerda, MD, E.E. Schneeberger, MD, M.A. Alfaro, MD, B.M. Roldán, MD, A.B. Gómez Vara, MD, P. Giorgis, MD, R.A. Ezquer, MD, M.G. Crespo Rocha, MD, C.R. Reyes Gómez, MD, M.Á. Correa, MD, M.G. Rosemffet, MD, V.C. Abarza, MD, M. Perandones, MD, G. Citera, MD, Instituto de Rehabilitación Psicofísica,
  • Roldán BM; O.L. Cerda, MD, E.E. Schneeberger, MD, M.A. Alfaro, MD, B.M. Roldán, MD, A.B. Gómez Vara, MD, P. Giorgis, MD, R.A. Ezquer, MD, M.G. Crespo Rocha, MD, C.R. Reyes Gómez, MD, M.Á. Correa, MD, M.G. Rosemffet, MD, V.C. Abarza, MD, M. Perandones, MD, G. Citera, MD, Instituto de Rehabilitación Psicofísica,
  • Gómez Vara AB; O.L. Cerda, MD, E.E. Schneeberger, MD, M.A. Alfaro, MD, B.M. Roldán, MD, A.B. Gómez Vara, MD, P. Giorgis, MD, R.A. Ezquer, MD, M.G. Crespo Rocha, MD, C.R. Reyes Gómez, MD, M.Á. Correa, MD, M.G. Rosemffet, MD, V.C. Abarza, MD, M. Perandones, MD, G. Citera, MD, Instituto de Rehabilitación Psicofísica,
  • Giorgis P; O.L. Cerda, MD, E.E. Schneeberger, MD, M.A. Alfaro, MD, B.M. Roldán, MD, A.B. Gómez Vara, MD, P. Giorgis, MD, R.A. Ezquer, MD, M.G. Crespo Rocha, MD, C.R. Reyes Gómez, MD, M.Á. Correa, MD, M.G. Rosemffet, MD, V.C. Abarza, MD, M. Perandones, MD, G. Citera, MD, Instituto de Rehabilitación Psicofísica,
  • Ezquer RA; O.L. Cerda, MD, E.E. Schneeberger, MD, M.A. Alfaro, MD, B.M. Roldán, MD, A.B. Gómez Vara, MD, P. Giorgis, MD, R.A. Ezquer, MD, M.G. Crespo Rocha, MD, C.R. Reyes Gómez, MD, M.Á. Correa, MD, M.G. Rosemffet, MD, V.C. Abarza, MD, M. Perandones, MD, G. Citera, MD, Instituto de Rehabilitación Psicofísica,
  • Crespo Rocha MG; O.L. Cerda, MD, E.E. Schneeberger, MD, M.A. Alfaro, MD, B.M. Roldán, MD, A.B. Gómez Vara, MD, P. Giorgis, MD, R.A. Ezquer, MD, M.G. Crespo Rocha, MD, C.R. Reyes Gómez, MD, M.Á. Correa, MD, M.G. Rosemffet, MD, V.C. Abarza, MD, M. Perandones, MD, G. Citera, MD, Instituto de Rehabilitación Psicofísica,
  • Reyes Gómez CR; O.L. Cerda, MD, E.E. Schneeberger, MD, M.A. Alfaro, MD, B.M. Roldán, MD, A.B. Gómez Vara, MD, P. Giorgis, MD, R.A. Ezquer, MD, M.G. Crespo Rocha, MD, C.R. Reyes Gómez, MD, M.Á. Correa, MD, M.G. Rosemffet, MD, V.C. Abarza, MD, M. Perandones, MD, G. Citera, MD, Instituto de Rehabilitación Psicofísica,
  • de Los Ángeles Correa M; O.L. Cerda, MD, E.E. Schneeberger, MD, M.A. Alfaro, MD, B.M. Roldán, MD, A.B. Gómez Vara, MD, P. Giorgis, MD, R.A. Ezquer, MD, M.G. Crespo Rocha, MD, C.R. Reyes Gómez, MD, M.Á. Correa, MD, M.G. Rosemffet, MD, V.C. Abarza, MD, M. Perandones, MD, G. Citera, MD, Instituto de Rehabilitación Psicofísica,
  • Rosemffet MG; O.L. Cerda, MD, E.E. Schneeberger, MD, M.A. Alfaro, MD, B.M. Roldán, MD, A.B. Gómez Vara, MD, P. Giorgis, MD, R.A. Ezquer, MD, M.G. Crespo Rocha, MD, C.R. Reyes Gómez, MD, M.Á. Correa, MD, M.G. Rosemffet, MD, V.C. Abarza, MD, M. Perandones, MD, G. Citera, MD, Instituto de Rehabilitación Psicofísica,
  • Abarza VC; O.L. Cerda, MD, E.E. Schneeberger, MD, M.A. Alfaro, MD, B.M. Roldán, MD, A.B. Gómez Vara, MD, P. Giorgis, MD, R.A. Ezquer, MD, M.G. Crespo Rocha, MD, C.R. Reyes Gómez, MD, M.Á. Correa, MD, M.G. Rosemffet, MD, V.C. Abarza, MD, M. Perandones, MD, G. Citera, MD, Instituto de Rehabilitación Psicofísica,
  • Pellet SC; M. Landi, MD, C. Calle Montoro, MD, S. Catalan Pellet, MD, C. Reimundes, MD, P. Maid, MD, Austral University Hospital, Rheumatology Department.
  • Perandones M; O.L. Cerda, MD, E.E. Schneeberger, MD, M.A. Alfaro, MD, B.M. Roldán, MD, A.B. Gómez Vara, MD, P. Giorgis, MD, R.A. Ezquer, MD, M.G. Crespo Rocha, MD, C.R. Reyes Gómez, MD, M.Á. Correa, MD, M.G. Rosemffet, MD, V.C. Abarza, MD, M. Perandones, MD, G. Citera, MD, Instituto de Rehabilitación Psicofísica,
  • Reimundes C; M. Landi, MD, C. Calle Montoro, MD, S. Catalan Pellet, MD, C. Reimundes, MD, P. Maid, MD, Austral University Hospital, Rheumatology Department.
  • Longueira Y; L. Cruces, BCh, Y. Longueira, MSc, G. Turk, PhD, M.F. Quiroga, PhD, N. Laufer, MD, PhD, Universidad de Buenos Aires, Consejo Nacional de Investigaciones Científicas y Técnicas, Instituto de Investigaciones Biomédicas en Retrovirus y Sida (INBIRS), Facultad de Medicina, Ciudad Autónoma de Buenos Aire
  • Turk G; L. Cruces, BCh, Y. Longueira, MSc, G. Turk, PhD, M.F. Quiroga, PhD, N. Laufer, MD, PhD, Universidad de Buenos Aires, Consejo Nacional de Investigaciones Científicas y Técnicas, Instituto de Investigaciones Biomédicas en Retrovirus y Sida (INBIRS), Facultad de Medicina, Ciudad Autónoma de Buenos Aire
  • Quiroga MF; L. Cruces, BCh, Y. Longueira, MSc, G. Turk, PhD, M.F. Quiroga, PhD, N. Laufer, MD, PhD, Universidad de Buenos Aires, Consejo Nacional de Investigaciones Científicas y Técnicas, Instituto de Investigaciones Biomédicas en Retrovirus y Sida (INBIRS), Facultad de Medicina, Ciudad Autónoma de Buenos Aire
  • Laufer N; L. Cruces, BCh, Y. Longueira, MSc, G. Turk, PhD, M.F. Quiroga, PhD, N. Laufer, MD, PhD, Universidad de Buenos Aires, Consejo Nacional de Investigaciones Científicas y Técnicas, Instituto de Investigaciones Biomédicas en Retrovirus y Sida (INBIRS), Facultad de Medicina, Ciudad Autónoma de Buenos Aire
  • Quintana R; R. Quintana, MD, G.J. Pons-Estel, MD, PhD, Research Unit - Argentine Society of Rheumatology.
  • de la Vega MC; M.C. de la Vega, MD, Argentine Society of Rheumatology.
  • Kreplak N; N. Kreplak, MD, MPH, M. Pifano, MSc, Ministry of Health of the Province of Buenos Aires, Buenos Aires, Argentina.
  • Pifano M; N. Kreplak, MD, MPH, M. Pifano, MSc, Ministry of Health of the Province of Buenos Aires, Buenos Aires, Argentina.
  • Maid P; M. Landi, MD, C. Calle Montoro, MD, S. Catalan Pellet, MD, C. Reimundes, MD, P. Maid, MD, Austral University Hospital, Rheumatology Department.
  • Pons-Estel GJ; R. Quintana, MD, G.J. Pons-Estel, MD, PhD, Research Unit - Argentine Society of Rheumatology.
  • Citera G; O.L. Cerda, MD, E.E. Schneeberger, MD, M.A. Alfaro, MD, B.M. Roldán, MD, A.B. Gómez Vara, MD, P. Giorgis, MD, R.A. Ezquer, MD, M.G. Crespo Rocha, MD, C.R. Reyes Gómez, MD, M.Á. Correa, MD, M.G. Rosemffet, MD, V.C. Abarza, MD, M. Perandones, MD, G. Citera, MD, Instituto de Rehabilitación Psicofísica,
J Rheumatol ; 49(12): 1385-1389, 2022 Dec.
Article in English | MEDLINE | ID: covidwho-2055490
ABSTRACT

OBJECTIVE:

The aim of this study was to assess the immune response after a third dose of SARS-CoV-2 vaccine in patients with rheumatoid arthritis (RA) with undetectable antibody titers after the primary regimen of 2 doses.

METHODS:

Patients with RA with no seroconversion after 2 doses of SARS-CoV-2 vaccine and who received a third dose of either an mRNA or vector-based vaccine were included. Anti-SARS-CoV-2 IgG antibodies, neutralizing activity, and T cell responses were assessed after the third dose.

RESULTS:

A total of 21 nonresponder patients were included. At the time of vaccination, 29% were receiving glucocorticoids and 85% biologic disease-modifying antirheumatic drugs (including 6 taking abatacept [ABA] and 4 taking rituximab [RTX]). The majority (95%) received the BNT162b2 vaccine and only one of them received the ChAdOx1 nCoV-19 vaccine. After the third dose, 91% of the patients presented detectable anti-SARS-CoV-2 IgG and 76% showed neutralizing activity. Compared to other treatments, ABA and RTX were associated with the absence of neutralizing activity in 4 out of 5 (80%) patients and lower titers of neutralizing antibodies (median 3, IQR 0-20 vs 8, IQR 4-128; P = 0.20). Specific T cell response was detected in 41% of all patients after the second dose, increasing to 71% after the third dose. The use of ABA was associated with a lower frequency of T cell response (33% vs 87%, P = 0.03).

CONCLUSION:

In this RA cohort, 91% of patients who failed to seroconvert after 2 doses of SARS-CoV-2 vaccine presented detectable anti-SARS-CoV-2 IgG after a third dose. The use of ABA was associated with a lower frequency of specific T cell response.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Arthritis, Rheumatoid / Vaccines / COVID-19 Type of study: Cohort study / Observational study / Prognostic study Topics: Vaccines Limits: Humans Language: English Journal: J Rheumatol Year: 2022 Document Type: Article

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Arthritis, Rheumatoid / Vaccines / COVID-19 Type of study: Cohort study / Observational study / Prognostic study Topics: Vaccines Limits: Humans Language: English Journal: J Rheumatol Year: 2022 Document Type: Article