Screening of active ingredients from traditional Chinese medicine against the novel Coronavirus based on molecular docking
Journal of Xinyang Normal University Natural Science Edition
; 33(2):210-219, 2020.
Article
in Chinese
| CAB Abstracts | ID: covidwho-2055548
ABSTRACT
ADMEN prediction was used to perform the first round screening from Traditional Chinese Medicine Database and Analysis Platform(TCMSP). then VASARA and molecular docking were used to screen again based on targets spike glyoprotein and angiotensin converting enzyme 2. and finally the interaction between target and drug was analyzed. 425 candidate ingredients of traditional Chinese medicine were screened from TCMSP database. when targeted by Spike glycoprotein. 12 ingredients were screened. They were contained artemisia apiacea salvia miltiorrhiza bge. scutellaria baicalensis. pinellia ternate. liquorice. radixImplettri and other traditional Chinese medicine. With ACE2 as the target. 77 components of traditional Chinese medicine were screened out. including salvia miltiorrhiza bge scutellaria baicalensis. pinellia ternatc. Liquorice. radix bupleuri. ephedra and other traditional Chinese medicine. At last. salviolone and dihydrotanshinlactone were found to be the potential inhibitor.
Horticultural Crops [FF003]; Plant Composition [FF040]; Pesticides and Drugs; Control [HH405]; Non-food/Non-feed Plant Products [SS200]; Prion, Viral, Bacterial and Fungal Pathogens of Humans [VV210]; traditional Chinese medicines; medicinal plants; glycoproteins; liquorice; plant composition; chemical composition; plant extracts; diterpenoids; coronavirus disease 2019; viral diseases; Artemisia apiacea; Salvia miltiorrhiza; Scutellaria baicalensis; Pinellia ternata; Glycyrrhiza glabra; Bupleurum; Ephedra; Severe acute respiratory syndrome coronavirus 2; plants; Glycyrrhiza; Artemisia; Asteraceae; Asterales; eudicots; angiosperms; Spermatophyta; eukaryotes; Salvia; Lamiaceae; Lamiales; Scutellaria; Pinellia; Araceae; Alismatales; monocotyledons; Papilionoideae; Fabaceae; Fabales; Apiaceae; Apiales; Ephedraceae; Gnetopsida; Gnetophyta; gymnosperms; Severe acute respiratory syndrome-related coronavirus; Betacoronavirus; Coronavirinae; Coronaviridae; Nidovirales; positive-sense ssRNA Viruses; ssRNA Viruses; RNA Viruses; viruses; drug plants; medicinal herbs; officinal plants; licorice; chemical constituents of plants; SARS-CoV-2; viral infections
Full text:
Available
Collection:
Databases of international organizations
Database:
CAB Abstracts
Topics:
Traditional medicine
Language:
Chinese
Journal:
Journal of Xinyang Normal University Natural Science Edition
Year:
2020
Document Type:
Article
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