A hospital based comparative study of the first and second waves of Covid-19 related multi-system inflammatory syndrome in children
Sri Lanka Journal of Child Health
; 51(3):431-435, 2022.
Article
in English
| Scopus | ID: covidwho-2055629
ABSTRACT
Introduction:
Studies have shown the differential impact of the second surge of acute Covid-19 infection, across age, clinical outcome and ethnicity. How these factors impact the clinical characteristics and outcome of multisystem inflammatory syndrome in children (MIS-C) is largely unknown.Objectives:
This hospital based comparative study was undertaken to analyse the clinical characteristics and outcomes of patients admitted with MIS-C during the two waves of Covid-19 infection in a tertiary care teaching hospital in South India.Method:
Patients admitted between September 2020 and October 2021 with MIS-C were included in this study. Patient demographics, laboratory values and treatment details were compared between the two surges of COVID 19 related MIS-C.Results:
Sixty-five children were admitted with MIS-C in the first wave and 73 in the second wave. More children were referred with a diagnosis of MIS-C in the second wave (p=0.001). There was no significant difference in the mean age or malefemale ratio between the two waves. A significantly higher proportion of children in the second wave had cervical lymphadenitis (p=0.02). Need for intensive care unit (ICU) admission (p<0.001), shock (p<0.001), respiratory support (p<0.001) and multiorgan involvement (p<0.001) were significantly lower in the second wave.Conclusions:
A significantly higher proportion of children with MIS-C in the second wave of Covid-19 infection had cervical lymphadenitis. The need for ICU admission, shock, respiratory support and multi-organ involvement were significantly lower in children with MIS-C in the second wave of Covid-19 infection © Open Access Article published under the Creative Commons Attribution CC-BY License
Full text:
Available
Collection:
Databases of international organizations
Database:
Scopus
Language:
English
Journal:
Sri Lanka Journal of Child Health
Year:
2022
Document Type:
Article
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