Your browser doesn't support javascript.
Exploring the globe salvaging treatment options in patients of COVID-19-associated mucormycosis with orbital involvement.
Khare, Praveen; Chaurasia, Yogita; Bhatnagar, Shweta.
  • Khare P; Department of Ophthalmology, Bundelkhand Medical College, Sagar, Madhya Pradesh, India.
  • Chaurasia Y; Department of Ophthalmology, Bundelkhand Medical College, Sagar, Madhya Pradesh, India.
  • Bhatnagar S; Department of Dentistry, Bundelkhand Medical College, Sagar, Madhya Pradesh, India.
Indian J Ophthalmol ; 70(10): 3638-3642, 2022 10.
Article in English | MEDLINE | ID: covidwho-2055709
ABSTRACT

Purpose:

To explore the various globe salvaging treatment strategies for patients with coronavirus disease 2019-associated mucormycosis (CAM).

Methods:

This was a prospective interventional analytical study conducted at a Medical College in rural India. A total of 84 patients of CAM admitted between May 2021 and August 2021 were enrolled for the study. Patients with histologically proven CAM with clinical and/or radiological evidence of orbital involvement were divided into three treatment categories based on the site and extent of the lesion. Re-assessment was performed after 7 days. For patients who worsened with the primary approach, orbital exenteration was considered based on a Sion Hospital Scoring System. A novel approach to intra-orbital anti-fungal therapy, site-centered peri-bulbar injection of amphotericin B (SCPeriAmB), was also explored. All the patients were followed up for at least 3 months. Convenience sampling with descriptive statistics was used.

Results:

Six patients had to finally undergo exenteration by the end of the study period. The rest of the patients were reported to be stable or improved. No mortalities were reported on delaying the exenteration. No adverse events were noted in patients who were given SCPeriAmB.

Conclusion:

Globe salvaging treatment options should be advocated as a primary approach in patients with CAM. Site-centered peri-bulbar injections can be considered as an approach for delivering intra-orbital anti-fungal therapy in selected patients.
Subject(s)
Keywords

Full text: Available Collection: International databases Database: MEDLINE Main subject: Orbital Diseases / Eye Infections, Fungal / COVID-19 / Mucormycosis Type of study: Cohort study / Diagnostic study / Observational study / Prognostic study Topics: Long Covid Limits: Humans Language: English Journal: Indian J Ophthalmol Year: 2022 Document Type: Article Affiliation country: Ijo.IJO_938_22

Similar

MEDLINE

...
LILACS

LIS


Full text: Available Collection: International databases Database: MEDLINE Main subject: Orbital Diseases / Eye Infections, Fungal / COVID-19 / Mucormycosis Type of study: Cohort study / Diagnostic study / Observational study / Prognostic study Topics: Long Covid Limits: Humans Language: English Journal: Indian J Ophthalmol Year: 2022 Document Type: Article Affiliation country: Ijo.IJO_938_22