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Secondary Failure of Tocilizumab in Treating Elderly-Onset Rheumatoid Arthritis With Systemic Symptoms Complicated by Diverticulum Perforation.
Takagi, Soshi; Naito, Yumi; Sano, Chiaki; Ohta, Ryuichi.
  • Takagi S; Family Medicine, Shimane University Medical School, Izumo, JPN.
  • Naito Y; Communiy Care, Unnan City Hospital, Unnan, JPN.
  • Sano C; Community Medicine Management, Shimane University Faculty of Medicine, Izumo, JPN.
  • Ohta R; Communiy Care, Unnan City Hospital, Unnan, JPN.
Cureus ; 14(8): e28357, 2022 Aug.
Article in English | MEDLINE | ID: covidwho-2056313
ABSTRACT
The treatment of rheumatoid arthritis (RA) has advanced from the use of steroids to disease-modifying anti-rheumatic drugs (DMARDs) and biologics such as tumor necrosis factor (TNF) and interleukin-6 (IL-6) inhibitors. Historically, steroids have been the mainstream in the clinical treatment of RA; however, the development of DMARDs has changed the RA treatment structure. In addition, biologics can alleviate RA symptoms. This case report describes the secondary failure of tocilizumab in treating RA with fatigue symptoms. Treatment with tocilizumab decreases C-reactive protein (CRP) levels, which may make detecting RA exacerbation difficult; therefore, obtaining the patient's precise history and thorough physical examinations are necessary. This case demonstrates the complexity of treating elderly-onset RA and reports practical methods for effective treatment.
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Full text: Available Collection: International databases Database: MEDLINE Type of study: Case report / Prognostic study Language: English Journal: Cureus Year: 2022 Document Type: Article

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Full text: Available Collection: International databases Database: MEDLINE Type of study: Case report / Prognostic study Language: English Journal: Cureus Year: 2022 Document Type: Article