Using laboratory parameters as predictors for the severity and mortality of COVID-19 in hospitalized patients.
Pharm Pract (Granada)
; 20(3): 2721, 2022.
Article
in English
| MEDLINE | ID: covidwho-2056673
ABSTRACT
Objective:
The aim of this study was to explore association of initial laboratory parameters of hospitalized patients with COVID-19, with the severity and death incident.Methods:
In this retrospective study, patients were classified based on mortality outcome (survivor and non-survivor) and disease severity (non-severe, severe, and critical). The initial laboratory data (within the first two days of hospital admission) were compared between these categories.Results:
Of 362 COVID-19 patients hospitalized between January-2021 and May-2021, 39.0% were non-severe, 32.2% severe, and 28.7% critical. 77.3% were lived and 22.7% died in hospital. Non-survivors were significantly older than survivors. There was a statistically significant association between exceeding the cut-points of laboratory parameters and the severity of the disease or even death. These laboratory parameters included D-dimer, C-reactive protein, prothrombin time, ferritin, white blood cells, neutrophil count, aspartate aminotransferase, creatinine, blood urea nitrogen, lymphocyte count, and albumin. Also, exceeding the cut-points of these parameters showed high odds of death. The highest odds ratio was reported for albumin <3.5 g/dL (OR=14.318 [4.784-42.851], p<0.001).Conclusion:
The cut-points of the laboratory parameters could effectively be used as predictors to assess the severity and risk of death to improve the management of COVID-19 patients.
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Type of study:
Observational study
/
Prognostic study
Language:
English
Journal:
Pharm Pract (Granada)
Year:
2022
Document Type:
Article
Affiliation country:
PharmPract.2022.3.2721
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