ROLE OF VITAMIN C IN THE TREATMENT AND PREVENTION OF COVID-19
International Journal of Medical Dentistry
; 26(3):398-410, 2022.
Article
in English
| ProQuest Central | ID: covidwho-2057446
ABSTRACT
Pathophysiologically, SARS-CoV-2 is similar to SARS-CoV-1, causing a strong characteristic inflammatory reaction that damages the airways [8]. [...]combined antiviral and host responses contribute to disease severity, as seen in cases of SARS-CoV-1 and MERS-CoV infections [9]. [...]a spurt of cytokines released in response to viral infection results in cytokine storm and sepsis, leading to a mortality rate of 28% in critical COVID-19 cases [10]. [...]SARS-CoV-2 decreases ACE2 receptor expression, which is associated with acute lung injury and disease pathology. Since ACE2 controls the renin-angiotensin system (RAS), its suppression can impair RAS homeostasis and influence blood pressure, electrolyte equilibrium, inflammation, and vascular permeability in the airways [14]. The enhanced requirement for antioxidants and consumption of vitamin C by leukocytes could explain the reduction in vitamin C levels observed during infections in general, during lung infections specifically [29], and in critically ill patients [30]. Besides the antioxidative effects of vitamin C, its beneficial functions during pneumonia act via signaling pathways associated with inflammation suppression and enhancement of immunoregulation [31].
Medical Sciences--Dentistry; Bronchopulmonary infection; Sepsis; Fatalities; Cytokine storm; Immunoregulation; Middle East respiratory syndrome; Mortality; Vitamin C; Ascorbic acid; Blood pressure; Lung diseases; Angiotensin-converting enzyme 2--ACE2; Renin; Permeability; Severe acute respiratory syndrome coronavirus 2; Viruses; Leukocytes; COVID-19; Homeostasis; Coronaviruses; Angiotensin; Inflammation
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Collection:
Databases of international organizations
Database:
ProQuest Central
Language:
English
Journal:
International Journal of Medical Dentistry
Year:
2022
Document Type:
Article
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