Echocardiographic Evaluation of Multisystem Inflammatory Syndrome in Children (MIS-C) Associated with COVID-19
Journal of Comprehensive Pediatrics
; 13(Supplement 1):19-20, 2022.
Article
in English
| EMBASE | ID: covidwho-2058537
ABSTRACT
Cardiac involvement is an observable issue in multisystem inflammatory syndrome in children (MIS-C) associ20 ated with COVID-19. The most common echocardiographic findings in MIS-C are abnormal coronary arteries, decreased left ventricular function, mitral regurgitation, and pericardial effusion. Abnormalities in the coronary arteries were seen in less than 20% of MIS-C patients. These abnormalities include dilatation or aneurysms in the coronary arteries;however, giant or large aneurysms are rare. On the other hand, transient coronary artery dilatation (which can occur secondary to viral myocarditis) may also mean that the coronary artery Z-scores never exceed 2.5. Reviewing large case series revealed that approximately 30 - 40% of MIS-C patients had decreased left ventricular function. In most cases, left ventricular function is mildly depressed, and severe left ventricular dysfunction was observed in only one-fifth of cases. Hypoxia, myocardial ischemia secondary to coronary involvement, stress-induced cardiomyopathy, injury caused by systemic inflammation, and viral myocarditis are the possible etiologies for the myocardial injury in MIS-C. It is now clear that myocardial strain imaging indices such as a global longitudinal strain (GLS), end-diastolic strain rate (EDSR), and peak left atrial strain (LAS) can demonstrate systolic or diastolic dysfunction in myocarditis patients with preserved left ventricular ejection fraction. Furthermore, right-sided ventricular deformation imaging abnormalities have been reported in adult patients with MIS-C. Less information is currently available on mitral regurgitation and pericardial effusion in pediatric patients with MIS-C;however, in an extensive study on 286 pediatric patients with MIS-C, 28% had pericardial effusion, and 42.7% had mitral regurgitation;both were mild in most patients.
Cardiac Involvement; covid-19; Pediatric; adult; case study; child; conference abstract; coronary artery aneurysm; coronary artery dilatation; coronavirus disease 2019; depression; diastolic dysfunction; female; global longitudinal strain; heart left atrium; heart left ventricle ejection fraction; heart left ventricle failure; heart left ventricle function; heart muscle injury; heart muscle ischemia; human; hypoxia; inflammation; major clinical study; male; mitral valve regurgitation; myocarditis; pediatric multisystem inflammatory syndrome; pediatric patient; pericardial effusion; systolic dysfunction; takotsubo cardiomyopathy; virus myocarditis
Search on Google
Collection:
Databases of international organizations
Database:
EMBASE
Type of study:
Experimental Studies
Language:
English
Journal:
Journal of Comprehensive Pediatrics
Year:
2022
Document Type:
Article
Similar
MEDLINE
...
LILACS
LIS