Your browser doesn't support javascript.
Association Between Vaccination Status and Mortality Among Intubated Patients With COVID-19-Related Acute Respiratory Distress Syndrome.
Grapsa, Eirini; Adamos, Georgios; Andrianopoulos, Ioannis; Tsolaki, Vasiliki; Giannakoulis, Vassilis G; Karavidas, Nikitas; Giannopoulou, Vassiliki; Sarri, Katerina; Mizi, Eleftheria; Gavrielatou, Evdokia; Papathanakos, Georgios; Mantzarlis, Konstantinos D; Mastora, Zafeiria; Magira, Eleni; Koulouras, Vasilios; Kotanidou, Anastasia; Siempos, Ilias I.
  • Grapsa E; First Department of Critical Care Medicine and Pulmonary Services, Evangelismos Hospital, National and Kapodistrian University of Athens Medical School, Athens, Greece.
  • Adamos G; First Department of Critical Care Medicine and Pulmonary Services, Evangelismos Hospital, National and Kapodistrian University of Athens Medical School, Athens, Greece.
  • Andrianopoulos I; Department of Intensive Care Unit, University Hospital of Ioannina, Ioannina, Greece.
  • Tsolaki V; Critical Care Department, University Hospital of Larissa, Faculty of Medicine, University of Thessaly, Larissa, Greece.
  • Giannakoulis VG; First Department of Critical Care Medicine and Pulmonary Services, Evangelismos Hospital, National and Kapodistrian University of Athens Medical School, Athens, Greece.
  • Karavidas N; Critical Care Department, University Hospital of Larissa, Faculty of Medicine, University of Thessaly, Larissa, Greece.
  • Giannopoulou V; First Department of Critical Care Medicine and Pulmonary Services, Evangelismos Hospital, National and Kapodistrian University of Athens Medical School, Athens, Greece.
  • Sarri K; First Department of Critical Care Medicine and Pulmonary Services, Evangelismos Hospital, National and Kapodistrian University of Athens Medical School, Athens, Greece.
  • Mizi E; First Department of Critical Care Medicine and Pulmonary Services, Evangelismos Hospital, National and Kapodistrian University of Athens Medical School, Athens, Greece.
  • Gavrielatou E; First Department of Critical Care Medicine and Pulmonary Services, Evangelismos Hospital, National and Kapodistrian University of Athens Medical School, Athens, Greece.
  • Papathanakos G; Department of Intensive Care Unit, University Hospital of Ioannina, Ioannina, Greece.
  • Mantzarlis KD; Critical Care Department, University Hospital of Larissa, Faculty of Medicine, University of Thessaly, Larissa, Greece.
  • Mastora Z; First Department of Critical Care Medicine and Pulmonary Services, Evangelismos Hospital, National and Kapodistrian University of Athens Medical School, Athens, Greece.
  • Magira E; First Department of Critical Care Medicine and Pulmonary Services, Evangelismos Hospital, National and Kapodistrian University of Athens Medical School, Athens, Greece.
  • Koulouras V; Department of Intensive Care Unit, University Hospital of Ioannina, Ioannina, Greece.
  • Kotanidou A; First Department of Critical Care Medicine and Pulmonary Services, Evangelismos Hospital, National and Kapodistrian University of Athens Medical School, Athens, Greece.
  • Siempos II; First Department of Critical Care Medicine and Pulmonary Services, Evangelismos Hospital, National and Kapodistrian University of Athens Medical School, Athens, Greece.
JAMA Netw Open ; 5(10): e2235219, 2022 10 03.
Article in English | MEDLINE | ID: covidwho-2059198
ABSTRACT
Importance Although vaccination substantially reduces the risk of severe COVID-19, it is yet unknown whether vaccinated patients who develop COVID-19 and require invasive mechanical ventilation have lower mortality than controls.

Objective:

To examine the association between COVID-19 vaccination status and mortality among critically ill patients who require invasive mechanical ventilation owing to acute respiratory distress syndrome (ARDS) related to COVID-19. Design, Setting, and

Participants:

This multicenter cohort study was performed between June 7, 2021, and February 1, 2022, among 265 consecutive adult patients with COVID-19 in academic intensive care units who underwent invasive mechanical ventilation owing to ARDS. Exposures Patients in the full vaccination group had completed the primary COVID-19 vaccination series more than 14 days but less than 5 months prior to intubation. This time threshold was chosen because guidelines from the US Centers for Disease Control and Prevention recommend a booster dose beyond that time. The remaining patients (ie, those who were unvaccinated, partially vaccinated, or fully vaccinated <14 days or >5 months before intubation) comprised the control group. Main Outcomes and

Measures:

The primary outcome was time from intubation to all-cause intensive care unit mortality. A Cox proportional hazards regression model including vaccination status, age, comorbid conditions, and baseline Sequential Organ Failure Assessment score on the day of intubation was used.

Results:

A total of 265 intubated patients (170 men [64.2%]; median age, 66.0 years [IQR, 58.0-76.0 years]; 26 [9.8%] in the full vaccination group) were included in the study. A total of 20 patients (76.9%) in the full vaccination group received the BNT162b2 vaccine, and the remaining 6 (23.1%) received the ChAdOx1 nCoV-19 vaccine. Patients in the full vaccination group were older (median age, 72.5 years [IQR, 62.8-80.0 years] vs 66.0 years [IQR, 57.0-75.0 years]) and more likely to have comorbid conditions (24 of 26 [92.3%] vs 160 of 239 [66.9%]), including malignant neoplasm (6 of 26 [23.1%] vs 18 of 239 [7.5%]), than those in the control group. Full vaccination status was significantly associated with lower mortality compared with controls (16 of 26 patients [61.5%] died in the full vaccination group vs 163 of 239 [68.2%] in the control group; hazard ratio, 0.55 [95% CI, 0.32-0.94]; P = .03). Conclusions and Relevance In this cohort study, full vaccination status was associated with lower mortality compared with controls, which suggests that vaccination might be beneficial even among patients who were intubated owing to COVID-19-related ARDS. These results may inform discussions with families about prognosis.
Subject(s)

Full text: Available Collection: International databases Database: MEDLINE Main subject: Respiratory Distress Syndrome / COVID-19 Type of study: Cohort study / Experimental Studies / Observational study / Prognostic study Topics: Long Covid / Vaccines Limits: Adult / Aged / Humans / Male Country/Region as subject: North America Language: English Journal: JAMA Netw Open Year: 2022 Document Type: Article Affiliation country: Jamanetworkopen.2022.35219

Similar

MEDLINE

...
LILACS

LIS


Full text: Available Collection: International databases Database: MEDLINE Main subject: Respiratory Distress Syndrome / COVID-19 Type of study: Cohort study / Experimental Studies / Observational study / Prognostic study Topics: Long Covid / Vaccines Limits: Adult / Aged / Humans / Male Country/Region as subject: North America Language: English Journal: JAMA Netw Open Year: 2022 Document Type: Article Affiliation country: Jamanetworkopen.2022.35219