The First 5 Years of Uterus Transplant in the US: A Report From the United States Uterus Transplant Consortium.
JAMA Surg
; 157(9): 790-797, 2022 09 01.
Article
in English
| MEDLINE | ID: covidwho-2059236
ABSTRACT
Importance Uterus transplant is a viable surgical treatment for women affected by absolute uterine-factor infertility, which affects 1 in 500 women. Objective:
To review transplant and birth outcomes of uterus transplant recipients in the US since the first case in 2016. Design, Setting, andParticipants:
In this cohort study, 5 years of uterus transplant outcome data were collected from the 3 centers performing uterus transplants in the US Baylor University Medical Center, Dallas, Texas; Cleveland Clinic, Cleveland, Ohio; and University of Pennsylvania, Philadelphia. A total of 33 women with absolute uterine-factor infertility who underwent uterus transplant between February 2016 and September 2021 were included. Main Outcomes andMeasures:
Graft survival, live birth, and neonatal outcome.Results:
Of the 33 included uterus transplant recipients, 2 (6%) were Asian, 1 (3%) was Black, 1 (3%) was South Asian, and 29 (88%) were White; the mean (SD) age was 31 (4.7) years; and the mean (SD) body mass index (calculated as weight in kilograms divided by height in meters squared) was 24 (3.6). Most uterus transplant recipients (31 of 33 [94%]) had a congenitally absent uterus (Mayer-Rokitansky-Küster-Hauser syndrome), and 21 of 33 (64%) received organs from living donors. Mean (range) follow-up was 36 (1-67) months. There was no donor or recipient mortality. One-year graft survival was 74% (23 of 31 recipients). Through October 2021, 19 of 33 recipients (58%) had delivered 21 live-born children. Among recipients with a viable graft at 1 year, the proportion with a live-born child was 83% (19 of 23). The median (range) gestational age at birth of neonates was 36 weeks 6 days (30 weeks, 1 day to 38 weeks), and the median (range) birth weight was 2860 (1310-3940) g (median [range], 58th [6th-98th] percentile). No congenital malformations were detected. Conclusions and Relevance Uterus transplant is a surgical therapy that enables women with uterine-factor infertility to successfully gestate and deliver children. Aggregate data from US centers demonstrate safety for the recipient, living donor, and child. These data may be used to counsel women with uterine-factor infertility on treatment options.
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Main subject:
46, XX Disorders of Sex Development
/
Infertility, Female
Type of study:
Cohort study
/
Observational study
/
Prognostic study
Limits:
Adult
/
Child
/
Female
/
Humans
/
Infant, Newborn
Country/Region as subject:
North America
Language:
English
Journal:
JAMA Surg
Year:
2022
Document Type:
Article
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