Mechanistic Basis of Regulation of Host Epigenetic Landscape and Its Association with Immune Function: A COVID19 Perspective

ABSTRACT

In the twenty-first century emergence, the rapid spread and pathogenicity associated with SARS-CoV-2 have put a tremendous impact on the human population leading to the COVID19 pandemic. Several theories, seminal findings, and mechanistic evidence have been proposed to understand the pathogenesis, origin, host immune response, and therapeutic approach. Although a coordinated effort by several countries enabled the vaccination drive to be successful, there is still a large gap between host epigenetic architecture and virus, which necessitates a deep understanding of the molecular basis of epigenetic interplay between virus and host modulating immune function. It is noteworthy to consider that virus-induced alteration in chromatin marks, especially in histone and DNA, plays an essential role in driving immunopathogenesis. In this backdrop, several question marks arise how the phenomenon occurs, what modifications are altered, how it is associated with immune function, and what epigenetic modulators could be adapted in clinical settings are poorly understood. In this chapter, we have discussed the cutting-edge aspect of the epigenetic basis of immune function and its current advancement for better therapeutic options in a clinical setting. © 2022, The Author(s), under exclusive license to Springer Nature Switzerland AG.