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SARS-CoV-2 Vaccines: Types, Working Principle, and Its Impact on Thrombosis and Gastrointestinal Disorders.
Khare, Shubhra; Singh, Ajey; Hussain, Imtiyaz; Singh, Narsingh Bahadur; Singh, Subhash.
  • Khare S; Plant Physiology Laboratory, Department of Botany, University of Allahabad, Prayagraj, 211002, U.P., India.
  • Niharika; Plant Physiology Laboratory, Department of Botany, University of Allahabad, Prayagraj, 211002, U.P., India.
  • Singh A; Department of Botany, University of Lucknow, Lucknow, 226007, U.P., India.
  • Hussain I; Government Degree College, University of Ladakh, Dras, Ladakh, India.
  • Singh NB; Plant Physiology Laboratory, Department of Botany, University of Allahabad, Prayagraj, 211002, U.P., India. singhnb166@gmail.com.
  • Singh S; The Institute of Optics, University of Rochester, Rochester, NY-14627, USA. ssingh49@ur.rochester.edu.
Appl Biochem Biotechnol ; 2022 Oct 12.
Article in English | MEDLINE | ID: covidwho-2231844
ABSTRACT
In the current scenario of the coronavirus pandemic caused by Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2), considerable efforts have been made to control the pandemic by the development of a strong immune system through massive vaccination. Just after the discovery of the genetic sequences of SARS-CoV-2, the development of vaccines became the prime focus of scientists around the globe. About 200 SARS-CoV-2 candidate vaccines have already been entered into preclinical and clinical trials. Various traditional and novel approaches are being utilized as a broad range of platforms. Viral vector (replicating and non-replicating), nucleic acid (DNA and RNA), recombinant protein, virus-like particle, peptide, live attenuated virus, an inactivated virus approaches are the prominent attributes of the vaccine development. This review article includes the current knowledge about the platforms used for the development of different vaccines, their working principles, their efficacy, and the impacts of COVID-19 vaccines on thrombosis. We provide a detailed description of the vaccines that are already approved by administrative authorities. Moreover, various strategies utilized in the development of emerging vaccines that are in the trial phases along with their mode of delivery have been discussed along with their effect on thrombosis and gastrointestinal disorders.
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Full text: Available Collection: International databases Database: MEDLINE Type of study: Experimental Studies / Prognostic study / Randomized controlled trials Topics: Vaccines Language: English Year: 2022 Document Type: Article Affiliation country: S12010-022-04181-3

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Full text: Available Collection: International databases Database: MEDLINE Type of study: Experimental Studies / Prognostic study / Randomized controlled trials Topics: Vaccines Language: English Year: 2022 Document Type: Article Affiliation country: S12010-022-04181-3