Covid-19, nervous system pathology, and Parkinson's disease: Bench to bedside.
Int Rev Neurobiol
; 165: 17-34, 2022.
Article
in English
| MEDLINE | ID: covidwho-2060263
ABSTRACT
Coronavirus disease 2019 (Covid-19) caused by Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) infection is primarily regarded as a respiratory disease; however, multisystemic involvement accompanied by a variety of clinical manifestations, including neurological symptoms, are commonly observed. There is, however, little evidence supporting SARS-CoV-2 infection of central nervous system cells, and neurological symptoms for the most part appear to be due to damage mediated by hypoxic/ischemic and/or inflammatory insults. In this chapter, we report evidence on candidate neuropathological mechanisms underlying neurological manifestations in Covid-19, suggesting that while there is mostly evidence against SARS-CoV-2 entry into brain parenchymal cells as a mechanism that may trigger Parkinson's disease and parkinsonism, that there are multiple means by which the virus may cause neurological symptoms.
Keywords
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Main subject:
Parkinson Disease
/
Central Nervous System Depressants
/
COVID-19
/
Nervous System Diseases
Type of study:
Prognostic study
Limits:
Humans
Language:
English
Journal:
Int Rev Neurobiol
Year:
2022
Document Type:
Article
Affiliation country:
Bs.irn.2022.06.006
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