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Covid-19, nervous system pathology, and Parkinson's disease: Bench to bedside.
Emmi, Aron; Boura, Iro; Raeder, Vanessa; Mathew, Donna; Sulzer, David; Goldman, James E; Leta, Valentina.
  • Emmi A; Institute of Human Anatomy, Department of Neuroscience, University of Padova, Padova, Italy.
  • Boura I; Department of Neurology, University Hospital of Heraklion, Crete, Greece.
  • Raeder V; Parkinson's Foundation Centre of Excellence, King's College Hospital NHS Foundation Trust, London, United Kingdom; Department of Neurology, Technical University Dresden, Dresden, Germany; Department of Basic and Clinical Neuroscience, Institute of Psychiatry, Psychology & Neuroscience, King'
  • Mathew D; Neuroscience and Mental Health Research Institute, School of Medicine, Cardiff University, Cardiff, United Kingdom.
  • Sulzer D; Departments of Psychiatry, Neurology, Pharmacology, Columbia University Medical Center, New York State Psychiatric Institute, New York, United States.
  • Goldman JE; Department of Pathology and Cell Biology, and the Taub Institute for Research on Alzheimer's Disease and the Aging Brain, Vagelos College of Physicians and Surgeons, Columbia University and the New York Presbyterian Hospital, New York, NY, United States.
  • Leta V; Parkinson's Foundation Centre of Excellence, King's College Hospital NHS Foundation Trust, London, United Kingdom; Department of Basic and Clinical Neuroscience, Institute of Psychiatry, Psychology & Neuroscience, King's College London, London, United Kingdom. Electronic address: valentina.l
Int Rev Neurobiol ; 165: 17-34, 2022.
Article in English | MEDLINE | ID: covidwho-2060263
ABSTRACT
Coronavirus disease 2019 (Covid-19) caused by Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) infection is primarily regarded as a respiratory disease; however, multisystemic involvement accompanied by a variety of clinical manifestations, including neurological symptoms, are commonly observed. There is, however, little evidence supporting SARS-CoV-2 infection of central nervous system cells, and neurological symptoms for the most part appear to be due to damage mediated by hypoxic/ischemic and/or inflammatory insults. In this chapter, we report evidence on candidate neuropathological mechanisms underlying neurological manifestations in Covid-19, suggesting that while there is mostly evidence against SARS-CoV-2 entry into brain parenchymal cells as a mechanism that may trigger Parkinson's disease and parkinsonism, that there are multiple means by which the virus may cause neurological symptoms.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Parkinson Disease / Central Nervous System Depressants / COVID-19 / Nervous System Diseases Type of study: Prognostic study Limits: Humans Language: English Journal: Int Rev Neurobiol Year: 2022 Document Type: Article Affiliation country: Bs.irn.2022.06.006

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Parkinson Disease / Central Nervous System Depressants / COVID-19 / Nervous System Diseases Type of study: Prognostic study Limits: Humans Language: English Journal: Int Rev Neurobiol Year: 2022 Document Type: Article Affiliation country: Bs.irn.2022.06.006