Your browser doesn't support javascript.
Recent developments in lactose blend formulations for carrier-based dry powder inhalation.
Hebbink, Gerald A; Jaspers, Maarten; Peters, Harry J W; Dickhoff, Bastiaan H J.
  • Hebbink GA; DFE Pharma, Kleverstrasse 187, 47568 Goch, Germany. Electronic address: Gerald.Hebbink@dfepharma.com.
  • Jaspers M; DFE Pharma, Kleverstrasse 187, 47568 Goch, Germany.
  • Peters HJW; DFE Pharma, Kleverstrasse 187, 47568 Goch, Germany.
  • Dickhoff BHJ; DFE Pharma, Kleverstrasse 187, 47568 Goch, Germany.
Adv Drug Deliv Rev ; 189: 114527, 2022 Oct.
Article in English | MEDLINE | ID: covidwho-2060293
ABSTRACT
Lactose is the most commonly used excipient in carrier-based dry powder inhalation (DPI) formulations. Numerous inhalation therapies have been developed using lactose as a carrier material. Several theories have described the role of carriers in DPI formulations. Although these theories are valuable, each DPI formulation is unique and are not described by any single theory. For each new formulation, a specific development trajectory is required, and the versatility of lactose can be exploited to optimize each formulation. In this review, recent developments in lactose-based DPI formulations are discussed. The effects of varying the material properties of lactose carrier particles, such as particle size, shape, and morphology are reviewed. Owing to the complex interactions between the particles in a formulation, processing adhesive mixtures of lactose with the active ingredient is crucial. Therefore, blending and filling processes for DPI formulations are also reviewed. While the role of ternary agents, such as magnesium stearate, has increased, lactose remains the excipient of choice in carrier-based DPI formulations. Therefore, new developments in lactose-based DPI formulations are crucial in the optimization of inhalable medicine performance.
Subject(s)
Keywords

Full text: Available Collection: International databases Database: MEDLINE Main subject: Excipients / Lactose Limits: Humans Language: English Journal: Adv Drug Deliv Rev Journal subject: Pharmacology / Drug Therapy Year: 2022 Document Type: Article

Similar

MEDLINE

...
LILACS

LIS


Full text: Available Collection: International databases Database: MEDLINE Main subject: Excipients / Lactose Limits: Humans Language: English Journal: Adv Drug Deliv Rev Journal subject: Pharmacology / Drug Therapy Year: 2022 Document Type: Article