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Recombinant protein polymer-antibody conjugates for applications in nanotechnology and biomedicine.
Goncalves, Antonio G; Hartzell, Emily J; Sullivan, Millicent O; Chen, Wilfred.
  • Goncalves AG; Department of Chemical and Biomolecular Engineering, University of Delaware, 150 Academy Street, Newark, DE 19716, United States.
  • Hartzell EJ; Department of Chemical and Biomolecular Engineering, University of Delaware, 150 Academy Street, Newark, DE 19716, United States.
  • Sullivan MO; Department of Chemical and Biomolecular Engineering, University of Delaware, 150 Academy Street, Newark, DE 19716, United States. Electronic address: msullivan@udel.edu.
  • Chen W; Department of Chemical and Biomolecular Engineering, University of Delaware, 150 Academy Street, Newark, DE 19716, United States. Electronic address: wilfred@udel.edu.
Adv Drug Deliv Rev ; 191: 114570, 2022 Dec.
Article in English | MEDLINE | ID: covidwho-2060294
ABSTRACT
Currently, there are over 100 antibody-based therapeutics on the market for the treatment of various diseases. The increasing importance of antibody treatment is further highlighted by the recent FDA emergency use authorization of certain antibody therapies for COVID-19 treatment. Protein-based materials have gained momentum for antibody delivery due to their biocompatibility, tunable chemistry, monodispersity, and straightforward synthesis and purification. In this review, we discuss progress in engineering the molecular features of protein-based biomaterials, in particular recombinant protein polymers, for introducing novel functionalities and enhancing the delivery properties of antibodies and related binding protein domains.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Polymers / COVID-19 Drug Treatment Limits: Humans Language: English Journal: Adv Drug Deliv Rev Journal subject: Pharmacology / Drug Therapy Year: 2022 Document Type: Article Affiliation country: J.addr.2022.114570

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Polymers / COVID-19 Drug Treatment Limits: Humans Language: English Journal: Adv Drug Deliv Rev Journal subject: Pharmacology / Drug Therapy Year: 2022 Document Type: Article Affiliation country: J.addr.2022.114570