3D engineered tissue models for studying human-specific infectious viral diseases
Bioactive Materials
; 21:576-594, 2023.
Article
in English
| EMBASE | ID: covidwho-2060443
ABSTRACT
Viral infections cause damage to various organ systems by inducing organ-specific symptoms or systemic multi-organ damage. Depending on the infection route and virus type, infectious diseases are classified as respiratory, nervous, immune, digestive, or skin infections. Since these infectious diseases can widely spread in the community and their catastrophic effects are severe, identification of their causative agent and mechanisms underlying their pathogenesis is an urgent necessity. Although infection-associated mechanisms have been studied in two-dimensional (2D) cell culture models and animal models, they have shown limitations in organ-specific or human-associated pathogenesis, and the development of a human-organ-mimetic system is required. Recently, three-dimensional (3D) engineered tissue models, which can present human organ-like physiology in terms of the 3D structure, utilization of human-originated cells, recapitulation of physiological stimuli, and tight cell-cell interactions, were developed. Furthermore, recent studies have shown that these models can recapitulate infection-associated pathologies. In this review, we summarized the recent advances in 3D engineered tissue models that mimic organ-specific viral infections. First, we briefly described the limitations of the current 2D and animal models in recapitulating human-specific viral infection pathology. Next, we provided an overview of recently reported viral infection models, focusing particularly on organ-specific infection pathologies. Finally, a future perspective that must be pursued to reconstitute more human-specific infectious diseases is presented. Copyright © 2022 The Authors
3D engineered tissue model; In vivo-mimicking; Infection route; Infectious viral disease; Pathology; antiretroviral therapy; antiviral activity; brain development; cell aggregation; Chikungunya virus; cytotoxicity; drug metabolism; drug release; electrophysiology; engineered tissue; herpes simplex; human; Human immunodeficiency virus; Human respiratory syncytial virus; immune response; Influenza A virus; integumentary system; Japanese encephalitis virus group; Measles virus; molecular dynamics; nervous system development; nonhuman; Norovirus; protein expression; respiratory system; review; SARS coronavirus; spheroid cell; three dimensional printing; tissue engineering; two dimensional cell culture; upregulation; Varicella zoster virus; virus infection; virus replication; Zika virus; angiotensin converting enzyme 2; hydrogel; organ on a chip
Full text:
Available
Collection:
Databases of international organizations
Database:
EMBASE
Language:
English
Journal:
Bioactive Materials
Year:
2023
Document Type:
Article
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