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Molecular insight into pentraxin-3: Update advances in innate immunity, inflammation, tissue remodeling, diseases, and drug role.
Zhang, Hao; Wang, Ruixuan; Wang, Zeyu; Wu, Wantao; Zhang, Nan; Zhang, Longbo; Hu, Jason; Luo, Peng; Zhang, Jian; Liu, Zaoqu; Feng, Songshan; Peng, Yun; Liu, Zhengzheng; Cheng, Quan.
  • Zhang H; Department of Neurosurgery, Xiangya Hospital, Central South University, China; National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, China; Department of Neurosurgery, The Second Affiliated Hospital, Chongqing Medical University, China.
  • Wang R; Department of Oncology, Xiangya Hospital, Central South University, China; National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, China.
  • Wang Z; Department of Neurosurgery, Xiangya Hospital, Central South University, China; National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, China.
  • Wu W; Department of Oncology, Xiangya Hospital, Central South University, China; National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, China.
  • Zhang N; Department of Neurosurgery, Xiangya Hospital, Central South University, China; One-third Lab, College of Bioinformatics Science and Technology, Harbin Medical University, China.
  • Zhang L; Department of Neurosurgery, Xiangya Hospital, Central South University, China; Department of Neurosurgery, and Department of Cellular & Molecular Physiology,Yale University School of Medicine, USA; National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South Univers
  • Hu J; Department of Neonatology, Yale University School of Medicine, USA.
  • Luo P; Department of Oncology, Zhujiang Hospital, Southern Medical University, China.
  • Zhang J; Department of Oncology, Zhujiang Hospital, Southern Medical University, China.
  • Liu Z; Department of Interventional Radiology, The First Affiliated Hospital of Zhengzhou University, China.
  • Feng S; Department of Neurosurgery, Xiangya Hospital, Central South University, China; National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, China.
  • Peng Y; Department of Geriatrics, Xiangya Hospital, Central South University, China; National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, China.
  • Liu Z; Department of Oncology, Xiangya Hospital, Central South University, China; National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, China. Electronic address: liuzhzheng@csu.edu.cn.
  • Cheng Q; Department of Neurosurgery, Xiangya Hospital, Central South University, China; National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, China. Electronic address: chengquan@csu.edu.cn.
Biomed Pharmacother ; 156: 113783, 2022 Dec.
Article in English | MEDLINE | ID: covidwho-2060453
ABSTRACT
Pentraxin-3 (PTX3) is the prototype of the long pentraxin subfamily, an acute-phase protein consisting of a C-terminal pentraxin domain and a unique N-terminal domain. PTX3 was initially isolated from human umbilical vein endothelial cells and human FS-4 fibroblasts. It was subsequently found to be also produced by synoviocytes, chondrocytes, osteoblasts, smooth muscle cells, myeloid dendritic cells, epithelial cells, and tumor cells. Various modulatory factors, such as miRNAs, cytokines, drugs, and hypoxic conditions, could regulate the expression level of PTX3. PTX3 is essential in regulating innate immunity, inflammation, angiogenesis, and tissue remodeling. Besides, PTX3 may play dual (pro-tumor and anti-tumor) roles in oncogenesis. PTX3 is involved in the occurrence and development of many non-cancerous diseases, including COVID-19, and might be a potential biomarker indicating the prognosis, activity,and severity of diseases. In this review, we summarize and discuss the potential roles of PTX3 in the oncogenesis and pathogenesis of non-cancerous diseases and potential targeted therapies based on PTX3.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Endothelial Cells / COVID-19 Drug Treatment Type of study: Prognostic study Limits: Humans Language: English Journal: Biomed Pharmacother Year: 2022 Document Type: Article Affiliation country: J.biopha.2022.113783

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Endothelial Cells / COVID-19 Drug Treatment Type of study: Prognostic study Limits: Humans Language: English Journal: Biomed Pharmacother Year: 2022 Document Type: Article Affiliation country: J.biopha.2022.113783