STUDY ON OUTCOMES OF NONINVASIVE VENTILATION IN PATIENTS WITH RESPIRATORY FAILURE AND FACTORS DETERMINING OUTCOME

ABSTRACT

SESSION TITLE Late Breaking Posters in Critical Care SESSION TYPE Original Investigation Posters PRESENTED ON 10/18/2022 0130 pm - 0230 pm PURPOSE: Respiratory failure is a life threatening emergency and the management of respiratory failure includes invasive or non-invasive ventilation based on the various clinical parameters. Hence the present study was conducted to assess the outcome of NIV in patients with respiratory failure and to determine the factors predicting the outcome. METHODS: This Prospective observational study had included a total of 104 subjects.The demographic details, clinical examination,vitals and arterial blood gas levels at 0,1, 4 and 24 hours were analyzed among study subjects. Descriptive analysis was carried out, that include mean and standard deviation for quantitative variables, frequency and proportion for categorical variables.Parametric statistics used were paired t test and ANOVA.Non parametric statistics used were Chisquare test.At 95% Confidence interval, p value of <0.05 was considered to be statistically significant. Multivariate Regression analysis was done to predict the factors determining outcome of NIV. The data was entered in excel sheet and analyzed using SPSS (Version 16). RESULTS: The mean age of the study population was 52.88±16.58 years.70.78% success rate was found among males and 29.23% success rate was found among females. The difference between gender and outcome was not statistically significant.There was no statistical significant association observed between BMI and outcome of NIV ( p value 0.84).Higher rate of success was seen among subjects with COPD (43.37%) followed by COVID 19 patients (18.07%), acute pulmonary edema and pneumonia (9.64% each), ARDS (8.43%).In our study, the difference between etiological diagnosis and outcome was found to be statistically significant in ARDS (P value 0.02), pneumonia (P value 0.04) and COPD (P value 0.007). Patients with GCS < 8, 12% were successful and GCS >8, 78.48% were successful. The difference between GCS and outcome was found to be statistically significant (P value <0.0001). All ABG parameters at 0, 1, 4 and 24 hours (except PaCo2 at 4 and 24 hours) were statistically significant to predict outcome of NIV. CONCLUSIONS: A successful outcome of 62.5% was observed in the subjects initiated on NIV for respiratory failure, COPD being the major etiological diagnosis and the factors determing NIV were based on etiological diagnosis, GCS and Arterial Blood gas parameters. CLINICAL IMPLICATIONS Though studies on outcome of NIV are available involving multiple variables including sociodemographic data, clinical and ABG parameters, there are only limited Indian studies to determine NIV outcome based on etiological diagnosis, comorbidities, GCS and ABG parameters at different time intervals affecting outcome of NIV in respiratory failure.Thus, the present study was conducted to study the outcome of non-invasive ventilation in patients with respiratory failure and to determine the above factors that affect the outcome of non-invasive ventilation DISCLOSURES No relevant relationships by Sahana K No relevant relationships by SURESH SAGADEVAN