CAN THE SYSTEMIC IMMUNE-INFLAMMATION INDEX, THE NEUTROPHIL-LYMPHOCYTE RATIO, AND THE PLATELET-LYMPHOCYTE RATIO HELP ASSESS PROGNOSIS OF SARS-COV-2 PNEUMONIA?

ABSTRACT

SESSION TITLE Late Breaking Chest Infections Posters SESSION TYPE Original Investigation Posters PRESENTED ON 10/18/2022 0130 pm - 0230 pm PURPOSE: To identify the association between SII, NLR and PLR and the prognosis in SARS-CoV-2 pneumonia. METHODS: A cross-sectional study that took place in Tacuba General Hospital, Mexico City. Adults hospitalized with SARS-CoV-2 infection were included. Descriptive statistic was made using Mann-Whitney's U test. Spearman’s Rank correlation coefficient was calculated. The risk of invasive mechanical ventilation (IMV) and mortality was calculated for each index with logistic regression. The analysis was made using the STATA 14.0 program. RESULTS: The current analysis included 295 subjects, 64% men. There was difference in SII and NLR levels between subjects who died and those who did not. Females with acute respiratory distress syndrome had a positive correlation for each index and length of stay for SII rs=0.739;for NLR rs=0.689;for PLR rs=0.649. Males had weak correlations. The risk of IMV with SII exceeding its cutoff value had an odds ratio of 2.50 (95% CI 1.38-4.51);a higher risk for IMV with NLR above its reference was detected (OR 2.34, 95% CI 1.36-4.05). Also, the elevated SII and NLR levels had an increased risk of mortality;for SII an OR 2.54 (95% CI 1.55-4.15);for NLR an OR 2.16 (95% CI 1.35-3.46). Statistical significance was considered with p=<0.05. CONCLUSIONS: These indexes are an accessible and low-cost tool that can help assess the prognosis of patients hospitalized for SARS-CoV-2 pneumonia. CLINICAL IMPLICATIONS The SII, NLR and PLR could be useful in identifying patients at risk of death or severe illness who require invasive mechanical ventilation in the earlier phase of SARS-CoV-2 pneumonia. As these indexes are easily quantified from blood sample data, they can reflect the body’s immune status and help assess the prognosis of SARS-CoV-2 pneumonia. DISCLOSURES No relevant relationships by Amaury Bravo Rodríguez No relevant relationships by JAVIER FIESCO PIÑA No relevant relationships by José Antonio García Cuéllar No relevant relationships by Ruben Antonio Gomez Mendoza No relevant relationships by Damayanty Gomez villanueva No relevant relationships by Karen Hopf Estandía No relevant relationships by Eduardo León Guadarrama No relevant relationships by Alma Daniela Martinez Carrillo No relevant relationships by José Peña Ramírez No relevant relationships by José Pérez Nieto No relevant relationships by Mariela Rosas García No relevant relationships by Fernando Sánchez Mata No relevant relationships by Damayanty Solis Contreras