The neurobiology of long COVID.

Monje, Michelle; Iwasaki, Akiko

Monje, Michelle; Iwasaki, Akiko.

Monje M; Department of Neurology, Stanford University, Stanford, CA 94305, USA; Howard Hughes Medical Institute, Stanford University, USA. Electronic address: mmonje@stanford.edu.
Iwasaki A; Department of Immunobiology, Yale University, New Haven, CT 06520, USA; Howard Hughes Medical Institute, Yale University, USA. Electronic address: akiko.iwasaki@yale.edu.

Neuron ; 110(21): 3484-3496, 2022 Nov 02.

Article in English | MEDLINE | ID: covidwho-2061716

ABSTRACT

ABSTRACT

Persistent neurological and neuropsychiatric symptoms affect a substantial fraction of people after COVID-19 and represent a major component of the post-acute COVID-19 syndrome, also known as long COVID. Here, we review what is understood about the pathobiology of post-acute COVID-19 impact on the CNS and discuss possible neurobiological underpinnings of the cognitive symptoms affecting COVID-19 survivors. We propose the chief mechanisms that may contribute to this emerging neurological health crisis.

Subject(s)

COVID-19; Mental Disorders; Nervous System Diseases; Humans; SARS-CoV-2; Post-Acute COVID-19 Syndrome

Keywords

COVID-19; EBV; HSV; PAISs; SARS-CoV-2; astrocytes; autoimmunity; blood-brain-barrier; cognitive impairment; hippocampal neurogenesis; long COVID; microglia; microvascular disease; myelin; post-acute infection syndromes

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Full text: Available Collection: International databases Database: MEDLINE Main subject: COVID-19 / Mental Disorders / Nervous System Diseases Type of study: Prognostic study Topics: Long Covid Limits: Humans Language: English Journal: Neuron Journal subject: Neurology Year: 2022 Document Type: Article

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