Single-centre study: MIS-C impact on blood pressure, coronary arteries and left ventricular function
Cardiology in the Young
; 32(Supplement 2):S241, 2022.
Article
in English
| EMBASE | ID: covidwho-2062124
ABSTRACT
Background and Aim:
MIS-C is a hyperinflammatory syndrome caused by Sars-CoV-2 virus. Cardiovascular system impairment is observed up to 100 % of all MIS-C patients with a wide spectrum and severity of symptoms. It is important to identify the course of the disease and its outcome, which could significantly improve public health. Method(s) A single-centre study, prospective cohort study, con-ducted in the Children's Clinical University hospital in Latvia from January to December 2021. Patients between the ages of one to seventeen years who met the MIS-C criteria were included in the study. We evaluated blood pressure, left ventricular heart func-tion, size of coronary arteries and hospital course. Result(s) Thirty-one patients were included who met the MIS-C criteria. The median age was 8.0 years, 52% were boys. Of all patients 77% initially presented with hypotension of whom 42% required inotropic support. Treatment in PICU was required in 58% of all patients. Reduced left ventricular ejection fraction was observed in 35% of all patients. Mildly decreased ventricular ejection fraction (lt;55%) was observed in 19% of cases but mod-erate dysfunction (ejection fraction lt;45%) was observed in 16% of patients. Twelve percent of patients received milrinone to improve left heart function. Left heart function significantly improved in all patients during the hospitalisation. In 6 % of all patients coronary artery dilations was observed. All patients had dilations resolution at the time of discharge. Median length of hospitalisation was twelve days and median length of PICU stay was three days. Conclusion(s) All patients cardiovascular symptoms had resolved at the time of discharge. Whether patients will have chronic cardiac impairment is unknown therefore it is crucial to perform long-term follow-up.
coronary artery dilation; MIS-C; Hypotension; adolescent; blood pressure; cardiovascular symptom; cardiovascular system; child; clinical article; cohort analysis; conference abstract; coronary artery dilatation; drug therapy; follow up; heart failure; heart function; heart left ventricle ejection fraction; heart left ventricle function; hospitalization; human; hypotension; infant; inotropism; Latvia; male; prospective study; public health; school child; university hospital; milrinone
Full text:
Available
Collection:
Databases of international organizations
Database:
EMBASE
Type of study:
Experimental Studies
Language:
English
Journal:
Cardiology in the Young
Year:
2022
Document Type:
Article
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