Engineering the next generation of cell-based therapeutics.
Nat Rev Drug Discov
; 21(9): 655-675, 2022 09.
Article
in English
| MEDLINE | ID: covidwho-2062224
ABSTRACT
Cell-based therapeutics are an emerging modality with the potential to treat many currently intractable diseases through uniquely powerful modes of action. Despite notable recent clinical and commercial successes, cell-based therapies continue to face numerous challenges that limit their widespread translation and commercialization, including identification of the appropriate cell source, generation of a sufficiently viable, potent and safe product that meets patient- and disease-specific needs, and the development of scalable manufacturing processes. These hurdles are being addressed through the use of cutting-edge basic research driven by next-generation engineering approaches, including genome and epigenome editing, synthetic biology and the use of biomaterials.
Full text:
Available
Collection:
International databases
Database:
MEDLINE
Main subject:
Cell- and Tissue-Based Therapy
/
Gene Editing
Type of study:
Prognostic study
Limits:
Humans
Language:
English
Journal:
Nat Rev Drug Discov
Journal subject:
Pharmacology
/
Drug Therapy
Year:
2022
Document Type:
Article
Affiliation country:
S41573-022-00476-6
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