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Lockdown measures during the COVID-19 pandemic strongly impacted the circulation of respiratory pathogens in Southern China.
Wang, Heping; Zheng, Yuejie; de Jonge, Marien I; Wang, Rongjun; Verhagen, Lilly M; Chen, Yunsheng; Li, Li; Xu, Zhi; Wang, Wenjian.
  • Wang H; Shenzhen Children's Hospital, No. 7019 Yitian Road, Futian District, Shenzhen, 518038, Guangdong, China.
  • Zheng Y; Department of Laboratory Medicine, Laboratory of Medical Immunology, Radboud Center for Infectious Diseases, Radboud University Medical Center, Nijmegen, The Netherlands.
  • de Jonge MI; Shenzhen Children's Hospital, No. 7019 Yitian Road, Futian District, Shenzhen, 518038, Guangdong, China.
  • Wang R; Department of Laboratory Medicine, Laboratory of Medical Immunology, Radboud Center for Infectious Diseases, Radboud University Medical Center, Nijmegen, The Netherlands.
  • Verhagen LM; Shenzhen Children's Hospital, No. 7019 Yitian Road, Futian District, Shenzhen, 518038, Guangdong, China.
  • Chen Y; Department of Laboratory Medicine, Laboratory of Medical Immunology, Radboud Center for Infectious Diseases, Radboud University Medical Center, Nijmegen, The Netherlands.
  • Li L; Department of Pediatric Infectious Diseases and Immunology, Amalia Children's Hospital, Radboud University Medical Center, Nijmegen, The Netherlands.
  • Xu Z; Shenzhen Children's Hospital, No. 7019 Yitian Road, Futian District, Shenzhen, 518038, Guangdong, China.
  • Wang W; Shenzhen Children's Hospital, No. 7019 Yitian Road, Futian District, Shenzhen, 518038, Guangdong, China.
Sci Rep ; 12(1): 16926, 2022 Oct 08.
Article in English | MEDLINE | ID: covidwho-2062269
ABSTRACT
A range of public health measures have been implemented to suppress local transmission of coronavirus disease 2019 (COVID-19) in Shenzhen. We examined the effect of these measures on the prevalence of respiratory pathogens in children. Clinical and respiratory pathogen data were collected for routine care from hospitalized children with acute respiratory infections in Shenzhen Children's Hospital from July 2018 to January 2022. Nasopharyngeal swabs were collected and respiratory pathogens were detected using standardized clinical diagnostics as part of routine care. Data were analyzed to describe the effects of COVID-19 prevention procedures on other common pathogens. A total of 56,325 children under 14 years of age were hospitalized with an acute respiratory infection during the study period, 33,909 were tested from July 2018 to January 2020 (pre-lockdown), 1168 from February 2020 to May 2020 (lockdown) and 21,248 from July 2020 to January 2022 (post-lockdown). We observed a 37.3% decline of routine care in respiratory infection associated hospital admission in the 19 months' post-lockdown vs. the 19 months' pre-lockdown. There were 99.4%, 16.0% and 1.26% reductions measured for Mycoplasma pneumoniae, influenza virus A and adenovirus, respectively. However, a 118.7% and 75.8% rise was found for respiratory syncytial virus (RSV) and human para-influenza virus (HPIV) during the 19 months' post-lockdown in comparison to the pre-pandemic period. The detection of RSV especially increased in toddlers after the lockdown. Lockdown measures during the COVID-19 pandemic led to a significant reduction of Mycoplasma pneumoniae, influenza virus A and adenovirus infection. In contrast, RSV and HPIV infection increased.
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Full text: Available Collection: International databases Database: MEDLINE Main subject: Orthomyxoviridae / Respiratory Tract Infections / Respiratory Syncytial Virus, Human / Adenoviridae Infections / COVID-19 Type of study: Experimental Studies / Observational study / Prognostic study Limits: Humans / Infant Country/Region as subject: Asia Language: English Journal: Sci Rep Year: 2022 Document Type: Article Affiliation country: S41598-022-21430-x

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Full text: Available Collection: International databases Database: MEDLINE Main subject: Orthomyxoviridae / Respiratory Tract Infections / Respiratory Syncytial Virus, Human / Adenoviridae Infections / COVID-19 Type of study: Experimental Studies / Observational study / Prognostic study Limits: Humans / Infant Country/Region as subject: Asia Language: English Journal: Sci Rep Year: 2022 Document Type: Article Affiliation country: S41598-022-21430-x